PUBLICATION

Origin of the zebrafish endocrine and exocrine pancreas

Authors

Ward, A.B., Warga, R.M., and Prince, V.E.

ID

ZDB-PUB-070513-5

Date

2007

Source

Developmental Dynamics : an official publication of the American Association of Anatomists 236(6): 1558-1569 (Journal)

Registered Authors

Prince, Victoria E., Ward, Andrea B., Warga, Rachel M.

Keywords

zebrafish, pancreas, fate map, insulin, islet, ventral pancreatic bud, dorsal pancreatic bud

MeSH Terms

Animals
Liver/cytology
Liver/embryology
Pancreas, Exocrine/cytology
Pancreas, Exocrine/embryology*
Stem Cells
Zebrafish/embryology*

PubMed

17474119 Full text @ Dev. Dyn.

Abstract

Here, we report a detailed fate map of the zebrafish pancreas at the early gastrula stage of development (6 hours postfertilization; hpf). We show that, at this stage, both pancreas and liver progenitors are symmetrically localized in two broad domains relative to the dorsal organizer. We demonstrate that the dorsal and ventral pancreatic buds can derive from common progenitor pools at 6 hpf, but often derive from independent populations. Endocrine vs. exocrine pancreas show a similar pattern of progenitors, consistent with descriptions of the dorsal bud being strictly endocrine and the ventral bud primarily exocrine. In general, we find that endocrine/dorsal bud progenitors are located more dorsally than the exocrine pancreas/ventral bud progenitors. Later in gastrulation (10 hpf), pancreas progenitors have migrated to bilateral domains at the equator of the embryo. Our fate map will assist with design and interpretation of future experiments to understand early pancreas development.

Genes / Markers

Figures

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Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Ward et al., 2007 ZDB-PUB-070513-5 PMID:17474119

Origin of the zebrafish endocrine and exocrine pancreas

Ward et al., 2007

ZDB-PUB-070513-5
PMID:17474119