PUBLICATION

Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

Authors

Gloriam, D.E., Schiöth, H.B., and Fredriksson, R.

ID

ZDB-PUB-050322-4

Date

2005

Source

Biochimica et biophysica acta. General subjects 1722(3): 235-246 (Journal)

Registered Authors

Fredriksson, Robert

Keywords

Rhodopsin; G-protein coupled receptor; Glutamate, Rhodopsin, adhesion, frizzled/taste2 and secretin; Monoamine; Orphan; Phylogeny

MeSH Terms

Expressed Sequence Tags
Humans
Phylogeny
Receptors, G-Protein-Coupled/chemistry
Receptors, G-Protein-Coupled/genetics*
Rhodopsin/chemistry
Rhodopsin/genetics*

PubMed

15777626 Full text @ BBA General Subjects

Abstract

We report nine new members of the Rhodopsin family of human G protein-coupled receptors (GPCRs) found by searches in the genome databases. BLAST searches and phylogenetic analyses showed that only four of the receptors are closely related to previously characterised GPCRs, GPR150 and GPR154 to oxytocin/vasopressin receptors, GPR152 to CRTH2/FPRs and GPR165 to GPR72/NPYR. Four of the receptors, GPR139, GPR146, GPR153 and GPR162, have one other orphan GPCRs as close relative while GPR148 lacks close relatives. We have identified in total 37 orthologues for the new receptors, primarily from rat, mouse, chicken, fugu and zebrafish. GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly. Analyses using expressed sequence tags (ESTs) indicate that all the new receptors except GPR153 have the CNS as a major site of expression.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Gloriam et al., 2005 ZDB-PUB-050322-4 PMID:15777626

Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

Gloriam et al., 2005

ZDB-PUB-050322-4
PMID:15777626