PUBLICATION
The use of mature zebrafish (Danio rerio) as a model for human aging and disease
- Authors
- Keller, E.T., and Murtha, J.M.
- ID
- ZDB-PUB-041111-10
- Date
- 2004
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 138(3): 335-341 (Review)
- Registered Authors
- Murtha, Jill
- Keywords
- Aging; Clinical pathology; Heat shock protein; Hematology; Hsf1; Hsp70; Longevity; Zebrafish
- MeSH Terms
-
- Aging/physiology*
- Animals
- Disease Models, Animal*
- Fish Diseases/metabolism
- Fish Diseases/pathology
- Heat-Shock Proteins/metabolism
- Humans
- Zebrafish/growth & development*
- Zebrafish/metabolism
- Zebrafish/physiology
- PubMed
- 15533791 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
Keller, E.T., and Murtha, J.M. (2004) The use of mature zebrafish (Danio rerio) as a model for human aging and disease. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):335-341.
Abstract
Zebrafish (Danio rerio) have been extensively utilized for understanding mechanisms of development. These studies have led to a wealth of resources including genetic tools, informational databases, and husbandry methods. In spite of all these resources, zebrafish have been underutilized for exploring pathophysiology of disease and the aging process. Zebrafish offer several advantages over mammalian models for these studies, including the ability to perform saturation mutagenesis and the capability to contain thousands of animals in a small space. In this review, we will discuss the use of mature zebrafish as an animal model and provide specific examples to support this novel use of zebrafish. Examples include demonstrating that clinical pathology can be performed in mature zebrafish and that age-associated changes in heat shock response can be observed in zebrafish. These highlights demonstrate the utility of zebrafish as a model for disease and aging.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping