PUBLICATION
Early vertebrate evolution of the TATA-binding protein, TBP
- Authors
- Bondareva, A.A., and Schmidt, E.E.
- ID
- ZDB-PUB-080825-2
- Date
- 2003
- Source
- Mol. Biol. Evol. 20(11): 1932-1939 (Journal)
- Registered Authors
- Keywords
- transcription, TFIID, cyclostome, minisatellite duplication, polypeptide genesis
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA, Complementary/metabolism
- Evolution, Molecular
- Exons
- Fishes
- Gene Library
- Introns
- Mice
- Models, Genetic
- Molecular Sequence Data
- Peptides/chemistry
- Phylogeny
- Protein Structure, Tertiary
- Species Specificity
- TATA-Box Binding Protein/genetics*
- PubMed
- 12885957 Full text @ Mol. Biol. Evol.
Citation
Bondareva, A.A., and Schmidt, E.E. (2003) Early vertebrate evolution of the TATA-binding protein, TBP. Mol. Biol. Evol.. 20(11):1932-1939.
Abstract
TBP functions in transcription initiation in all eukaryotes and in Archaebacteria. Although the 181-amino acid (aa) carboxyl (C-) terminal core of the protein is highly conserved, TBP proteins from different phyla exhibit diverse sequences in their amino (N-) terminal region. In mice, the TBP N-terminus plays a role in protecting the placenta from maternal rejection; however the presence of similar TBP N-termini in nontherian tetrapods suggests that this domain also has more primitive functions. To gain insights into the pretherian functions of the N-terminus, we investigated its phylogenetic distribution. TBP cDNAs were isolated from representative nontetrapod jawed vertebrates (zebrafish and shark), from more primitive jawless vertebrates (lamprey and hagfish), and from a prevertebrate cephalochordate (amphioxus). Results showed that the tetrapod N-terminus likely arose coincident with the earliest vertebrates. The primary structures of vertebrate N-termini indicates that, historically, this domain has undergone events involving intragenic duplication and modification of short oligopeptide-encoding DNA sequences, which might have provided a mechanism of de novo evolution of this polypeptide.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping