PUBLICATION
A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus
- Authors
- Petrella, J.E., Cohen, C.J., Gaetz, J., and Bergelson, J.M.
- ID
- ZDB-PUB-021002-3
- Date
- 2002
- Source
- Journal of virology 76(20): 10503-10506 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Adenoviruses, Human/metabolism*
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- CHO Cells
- Conserved Sequence
- Coxsackie and Adenovirus Receptor-Like Membrane Protein
- Cricetinae
- DNA, Complementary
- Enterovirus B, Human/metabolism*
- Humans
- Molecular Sequence Data
- Receptors, Virus/genetics
- Receptors, Virus/metabolism*
- Zebrafish
- PubMed
- 12239327 Full text @ J. Virol.
Citation
Petrella, J.E., Cohen, C.J., Gaetz, J., and Bergelson, J.M. (2002) A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus. Journal of virology. 76(20):10503-10506.
Abstract
In this study, a zebrafish homologue of the coxsackievirus and adenovirus receptor (CAR) protein was identified. Although the extracellular domain of zebrafish CAR (zCAR) is less than 50% identical to that of human CAR (hCAR), zCAR mediated infection of transfected cells by both adenovirus type 5 and coxsackievirus B3. CAR residues interacting deep within the coxsackievirus canyon are highly conserved in zCAR and hCAR, which is consistent with the idea that receptor contacts within the canyon are responsible for coxsackievirus attachment In contrast, CAR residues contacting the south edge of the canyon are not conserved, suggesting that receptor interaction with the viral "puff region" is not essential for attachment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping