PUBLICATION
Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development
- Authors
- Brown, N.L., Dagenais, S.L., Chen, C.M., and Glaser, T.
- ID
- ZDB-PUB-030728-22
- Date
- 2002
- Source
- Mammalian genome : official journal of the International Mammalian Genome Society 13(2): 95-101 (Journal)
- Registered Authors
- Brown, Nadean L.
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Chromosome Mapping*
- Chromosomes, Human, Pair 10
- DNA-Binding Proteins/genetics*
- Humans
- Mice
- Molecular Sequence Data
- Nerve Tissue Proteins/genetics*
- Phylogeny
- Retinal Ganglion Cells/cytology
- Retinal Ganglion Cells/physiology*
- Sequence Analysis, DNA*
- Synteny
- Transcription Factors/genetics*
- PubMed
- 11889557 Full text @ Mamm. Genome
Citation
Brown, N.L., Dagenais, S.L., Chen, C.M., and Glaser, T. (2002) Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. Mammalian genome : official journal of the International Mammalian Genome Society. 13(2):95-101.
Abstract
The human ATOH7 gene encodes a basic helix-loop-helix (bHLH) transcription factor that is highly similar to Drosophila Atonal within the conserved bHLH domain. The ATOH7 coding region is contained within a single exon. We mapped ATOH7 to Chromosome (Chr) 10q21.3-22.1, a region syntenic to the segment of mouse Chr 10 where Atoh7 (formerly Math5) is located. The evolutionary relationship between ATOH7 and other atonal homologs was investigated using parsimony analysis. A direct comparison of ATH5/7 and ATH1 protein subgroups to Atonal also revealed a nonrandom distribution of amino acid changes across the bHLH domain, which may be related to their separate visual and proprioceptive sensory functions. Among bHLH genes, ATOH7 is most closely related to Atoh7. This sequence conservation extends significantly beyond the coding region. We define blocks of strong homology in flanking human and mouse genomic DNA, which are likely to include cis regulatory elements. Because targeted deletion of Atoh7 causes optic nerve agenesis in mice, we propose ATOH7 as a candidate for human optic nerve aplasia and related clinical syndromes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping