PUBLICATION
Odorant receptor gene regulation: implications from genomic organization
- Authors
- Kratz, E., Dugas, J.C., and Ngai, J.
- ID
- ZDB-PUB-020111-1
- Date
- 2002
- Source
- Trends in genetics : TIG 18(1): 29-34 (Journal)
- Registered Authors
- Kratz, Erica, Ngai, John
- Keywords
- none
- MeSH Terms
-
- Alleles
- Animals
- Biological Evolution
- Gene Expression Regulation
- Genome
- Humans
- Mice
- Models, Genetic
- Multigene Family
- Olfactory Receptor Neurons/metabolism
- Receptors, Odorant/genetics*
- Zebrafish/genetics
- PubMed
- 11750698 Full text @ Trends Genet.
Citation
Kratz, E., Dugas, J.C., and Ngai, J. (2002) Odorant receptor gene regulation: implications from genomic organization. Trends in genetics : TIG. 18(1):29-34.
Abstract
Odorant receptor genes comprise the largest known family of G-protein-coupled receptors in vertebrates. These receptor genes are tightly clustered in the genomes of every vertebrate organism investigated, including zebrafish, mice and humans, and they appear to have expanded and duplicated throughout evolution. In a mechanism that has yet to be elucidated, each olfactory neuron expresses a single receptor gene. This highly restricted expression pattern underlies the ability to distinguish between a wide variety of odorants. Here, we address the evolutionary expansion of odorant receptor genes and the role genomic organization of these genes might have in their tightly regulated expression.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping