Burkhalter et al., 2019
- Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis.
The Journal of Clinical Investigation
130:2841-2855
Full text @ Journal of Clin. Invest.
| Human Disease | Fish | Environment | Evidence Code |
|---|---|---|---|
| ciliopathy |
WT WT WT + MO1-cox5aa |
chemical treatment: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one chemical treatment: rotenone standard conditions |
TAS
TAS TAS |
| mitochondrial metabolism disease |
WT WT |
chemical treatment: rotenone chemical treatment: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one |
TAS
TAS |
| visceral heterotaxy |
WT + MO1-cox5aa WT + MO1-mtrr WT + MO1-osbpl1a WT + MO1-phka2 WT + MO4-tafazzin WT WT |
standard conditions standard conditions standard conditions standard conditions standard conditions chemical treatment: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one chemical treatment: rotenone |
TAS
TAS TAS TAS TAS TAS TAS |