Gene

meox1

ID

ZDB-GENE-040718-149

Name

mesenchyme homeobox 1

Symbol

meox1 Nomenclature History

Previous Names

mox2 (1)
mox (1)
cho
choker (1)
id:ibd2838
zgc:92343

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hematopoietic stem cell differentiation; muscle cell development; and somite development. Localizes to nucleus. Used to study Klippel-Feil syndrome. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Is expressed in several structures, including fast muscle myoblast; medial rectus; paraxial mesoderm; pectoral fin; and tail bud. Orthologous to human MEOX1 (mesenchyme homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With meox1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Klippel-Feil syndrome 2	Alliance	Klippel-Feil syndrome 2	214300

Associated With meox1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Klippel-Feil syndrome	meox1^tm26/tm26 (TU)	standard conditions	Dauer et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR020479	Homeobox domain, metazoa
Family	IPR042634	Homeobox protein MOX-1/MOX-2
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily