Gene
insra
- ID
- ZDB-GENE-020503-3
- Name
- insulin receptor a
- Symbol
- insra Nomenclature History
- Previous Names
-
- IRa (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have insulin receptor substrate binding activity and insulin-activated receptor activity. Involved in chordate embryonic development and developmental growth. Predicted to localize to axon and insulin receptor complex. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Is expressed in several structures, including fertilized egg; immature eye; liver; male organism; and pleuroperitoneal region. Orthologous to human INSR (insulin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Donohue syndrome | Alliance | Donohue syndrome | 246200 |
| familial hyperinsulinemic hypoglycemia 5 | Alliance | Hyperinsulinemic hypoglycemia, familial, 5 | 609968 |
| Diabetes mellitus, insulin-resistant, with acanthosis nigricans | 610549 | ||
| Rabson-Mendenhall syndrome | 262190 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR040969 | Insulin receptor, trans-membrane domain |
| Family | IPR016246 | Tyrosine-protein kinase, insulin-like receptor |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Insulin receptor, trans-membrane domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, insulin-like receptor | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BIL6
|
1362 | |||||||||||||||||
|
UniProtKB:B7SNG4
|
1353 |
Interactions and Pathways
Plasmids
No data available