Gene

shox2

ID
ZDB-GENE-040426-1457
Name
shox homeobox 2
Symbol
shox2 Nomenclature History
Previous Names
  • zgc:65884
  • zgc:77344
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have sequence-specific DNA binding activity. Involved in heart development and regulation of heart contraction. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in lung cancer. Is expressed in apical ectodermal ridge pectoral fin bud; heart; nervous system; and pectoral fin. Orthologous to human SHOX2 (short stature homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With shox2 Human Ortholog
No data available
Associated With shox2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily OAR domain
UniProtKB:A0A8M9QLB7 233
UniProtKB:A0A8M9Q089 221
UniProtKB:A0A8M9QPS7 287
UniProtKB:Q7SZN8 299
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-shox2 monoclonal IgG2a , k Mouse
  • IHC
Abcam plc
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations