Gene

opn1lw1

ID

ZDB-GENE-990604-41

Name

opsin 1 (cone pigments), long-wave-sensitive, 1

Symbol

opn1lw1 Nomenclature History

Previous Names

LWS-1 (1)
LC opsin (1)
rdops
red-sensitive opsin (1)
zfred

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have G protein-coupled photoreceptor activity. Involved in photoperiodism. Predicted to localize to integral component of plasma membrane and photoreceptor outer segment. Human ortholog(s) of this gene implicated in blue cone monochromacy and red color blindness. Is expressed in several structures, including digestive system; endocrine system; heart; photoreceptor cell; and visual system. Orthologous to several human genes including OPN1LW (opsin 1, long wave sensitive).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

65 figures from 42 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:73027 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With opn1lw1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
blue cone monochromacy	Alliance	Blue cone monochromacy	303700
red color blindness	Alliance	Colorblindness, protan	303900

Associated With opn1lw1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR027430	Visual pigments (opsins) retinal binding site
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR000378	Opsin red/green sensitive
Family	IPR001760	Opsin

Domain Details Per Protein

Protein	Length	GPCR, rhodopsin-like, 7TM	G protein-coupled receptor, rhodopsin-like	Opsin	Opsin red/green sensitive	Visual pigments (opsins) retinal binding site
UniProtKB:A0A0N9N7J4 InterPro	357
UniProtKB:Q9W6A7 InterPro	357

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	opn1lw1-201 (1) Ensembl	Havana	1699 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	opn1lw1-002 (1) Ensembl	Havana	127 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-opn1lw1	polyclonal	opn1lw1		Rabbit	IHC		19
Ab2-opn1lw1		opn1lw1			IHC	ABclonal	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations