ZFIN Person: Otis, Jessica P.

ZFIN ID: ZDB-PERS-120625-1

ZFIN ID: ZDB-PERS-120625-1

Otis, Jessica P.

Email:	otis@ciwemb.edu
URL:	http://emb.carnegiescience.edu/labs/farber/index.php
Affiliation:
Address:	Carnegie Institution 3520 San Martin Dr. Baltimore MD 21218 USA
Country:	United States
Phone:	410 246 3028
Fax:	410 243 6311
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

I am interested in elucidating the role of intestinal caveolae in nutrient processing and systemic metabolism. Additionally, I investigate apolipoprotein metabolism.

I earned my Ph.D. from the University of Wisconsin-Madison in 2011 and am currently a postdoc in the Farber lab at the Carnegie Institution.

PUBLICATIONS

Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097

Otis, J.P., Shen, M.C., Caldwell, B.A., Reyes Gaido, O.E., Farber, S.A. (2019) Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine. American journal of physiology. Gastrointestinal and liver physiology. 316(3):G350-G365

Otis, J.P., Shen, M.C., Quinlivan, V., Anderson, J.L., Farber, S.A. (2017) Intestinal epithelial cell Caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels. Disease models & mechanisms. 10(3):283-295

Otis, J.P., Farber, S.A. (2016) High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake. Journal of visualized experiments : JoVE. (116)

Otis, J.P., Zeituni, E.M., Thierer, J.H., Anderson, J.L., Brown, A.C., Boehm, E.D., Cerchione, D.M., Ceasrine, A.M., Avraham-Davidi, I., Tempelhof, H., Yaniv, K., Farber, S.A. (2015) Zebrafish as a model for apolipoprotein biology: Comprehensive expression analysis and a role for ApoA-IV in regulating food intake. Disease models & mechanisms. 8(3):295-309

Otis, J.P., and Farber, S.A. (2013) Imaging vertebrate digestive function and lipid metabolism in vivo.. Drug Discovery Today: Disease Models. 10(1):e11-e16

NON-ZEBRAFISH PUBLICATIONS
Cholesterol and lipoprotein dynamics in a hibernating mammal. Otis JP, Sahoo D, Drover VA, Yen CL, Carey HV. PLoS One. 2011;6(12):e29111. Epub 2011 Dec 15.

Induction of torpor: mimicking natural metabolic suppression for biomedical applications. Bouma HR, Verhaag EM, Otis JP, Heldmaier G, Swoap SJ, Strijkstra AM, Henning RH, Carey HV. J Cell Physiol. 2012 Apr;227(4):1285-90. doi: 10.1002/jcp.22850. Review.

Cholecystokinin activation of central satiety centers changes seasonally in a mammalian hibernator. Otis JP, Raybould HE, Carey HV. Gen Comp Endocrinol. 2011 May 1;171(3):269-74. Epub 2011 Mar 21.

Global analysis of circulating metabolites in hibernating ground squirrels. Nelson CJ, Otis JP, Carey HV. Comp Biochem Physiol Part D Genomics Proteomics. 2010 Dec;5(4):265-73. Epub 2010 Jul 30.

Identification of qRT-PCR reference genes for analysis of opioid gene expression in a hibernator. Otis JP, Ackermann LW, Denning GM, Carey HV. J Comp Physiol B. 2010 Apr;180(4):619-29. Epub 2009 Dec 23.

A role for nuclear receptors in mammalian hibernation. Nelson CJ, Otis JP, Carey HV. J Physiol. 2009 May 1;587(Pt 9):1863-70. Epub 2009 Mar 16. Review.

Analysis of the hibernation cycle using LC-MS-based metabolomics in ground squirrel liver. Nelson CJ, Otis JP, Martin SL, Carey HV. Physiol Genomics. 2009 Mar 3;37(1):43-51. Epub 2008 Dec 23.

Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti ME. Diabetes. 2009 Feb;58(2):460-8. Epub 2008 Nov 18.

Hypoxic ventilatory responses in rats after hypercapnic hyperoxia and intermittent hyperoxia. Bavis RW, Russell KE, Simons JC, Otis JP. Respir Physiol Neurobiol. 2007 Mar 15;155(3):193-202. Epub 2006 Jun 23.

Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Jimenez-Chillaron JC, Hernandez-Valencia M, Lightner A, Faucette RR, Reamer C, Przybyla R, Ruest S, Barry K, Otis JP, Patti ME. Diabetologia. 2006 Aug;49(8):1974-84. Epub 2006 Jun 8.

Respiratory plasticity after perinatal hypercapnia in rats. Bavis RW, Johnson RA, Ording KM, Otis JP, Mitchell GS. Respir Physiol Neurobiol. 2006 Aug;153(1):78-91. Epub 2005 Dec 9.