ZFIN Person: Vanhollebeke, Benoit

ZFIN ID: ZDB-PERS-100823-16

ZFIN ID: ZDB-PERS-100823-16

Vanhollebeke, Benoit

Email:	benoit.vanhollebeke@ulb.be
URL:	http://nvasc.ulb.be/vanhollebekelab/
Affiliation:	Laboratory of Neurovascular Signaling
Address:	Laboratory of Neurovascular Signaling ULB Neuroscience Institute (UNI) Department of Molecular Biology University of Brussels (ULB), Belgium
Country:
Phone:	+322.650.97.61
Fax:	+322.650.97.67
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Van Dyck, A., Masin, L., Bergmans, S., Schevenels, G., Beckers, A., Vanhollebeke, B., Moons, L. (2023) A new microfluidic model to study dendritic remodeling and mitochondrial dynamics during axonal regeneration of adult zebrafish retinal neurons. Frontiers in molecular neuroscience. 16:11965041196504

Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:

Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097

America, M., Bostaille, N., Eubelen, M., Martin, M., Stainier, D.Y.R., Vanhollebeke, B. (2022) An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. Cell Reports. 39:110902

Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459

Jensen, L.D., Hot, B., Ramsköld, D., Germano, R.F.V., Yokota, C., Giatrellis, S., Lauschke, V.M., Hubmacher, D., Li, M.X., Hupe, M., Arnold, T.D., Sandberg, R., Frisén, J., Trusohamn, M., Martowicz, A., Wisniewska-Kruk, J., Nyqvist, D., Adams, R.H., Apte, S.S., Vanhollebeke, B., Stenman, J.M., Kele, J. (2019) Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 39:1432-1447

Campenhout, C.V., Cabochette, P., Veillard, A.C., Laczik, M., Zelisko-Schmidt, A., Sabatel, C., Dhainaut, M., Vanhollebeke, B., Gueydan, C., Kruys, V. (2019) Guidelines for optimized gene knockout using CRISPR/Cas9. Biotechniques. 66:295-302

Benz, F., Wichitnaowarat, V., Lehmann, M., Germano, R.F.V., Mihova, D., Macas, J., Adams, R.H., Taketo, M.M., Guérit, S., Plate, K.H., Vanhollebeke, B., Liebner, S. (2019) Low Wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. eLIFE. 8:

Bonnin, E., Cabochette, P., Filosa, A., Jühlen, R., Komatsuzaki, S., Hezwani, M., Dickmanns, A., Martinelli, V., Vermeersch, M., Supply, L., Martins, N., Pirenne, L., Ravenscroft, G., Lombard, M., Port, S., Spillner, C., Janssens, S., Roets, E., Van Dorpe, J., Lammens, M., Kehlenbach, R.H., Ficner, R., Laing, N.G., Hoffmann, K., Vanhollebeke, B., Fahrenkrog, B. (2018) Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. PLoS Genetics. 14:e1007845

Hübner, K., Cabochette, P., Diéguez-Hurtado, R., Wiesner, C., Wakayama, Y., Grassme, K.S., Hubert, M., Guenther, S., Belting, H.G., Affolter, M., Adams, R.H., Vanhollebeke, B., Herzog, W. (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nature communications. 9:4860

Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):

Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7

Bostaille, N., Gauquier, A., Stainier, D.Y., Raible, D.W., Vanhollebeke, B. (2017) Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants. Development (Cambridge, England). 144(1):8-11

Bostaille, N., Gauquier, A., Twyffels, L., Vanhollebeke, B. (2016) Molecular insights into Adgra2/Gpr124 and Reck intracellular trafficking. Biology Open. 5:1874-1881

Vanhollebeke, B., Stone, O.A., Bostaille, N., Cho, C., Zhou, Y., Maquet, E., Gauquier, A., Cabochette, P., Fukuhara, S., Mochizuki, N., Nathans, J., Stainier, D.Y. (2015) Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. eLIFE. 4

Housley, M.P., Reischauer, S., Dieu, M., Raes, M., Stainier, D.Y., Vanhollebeke, B. (2014) Translational profiling through biotinylation of tagged ribosomes in zebrafish. Development (Cambridge, England). 141(20):3988-93

NON-ZEBRAFISH PUBLICATIONS
De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234. doi: 10.1371/journal.pntd.0005234.

Uzureau S, Coquerelle C, Vermeiren C, Uzureau P, Van Acker A, Pilotte L, Monteyne D, Acolty V, Vanhollebeke B, Van den Eynde B, Pérez-Morga D, Moser M, Pays E. Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells. Eur J Immunol. 2016 Aug;46(8):1854-66. doi: 10.1002/eji.201546252.

Imamura H, Downing T, Van den Broeck F, Sanders MJ, Rijal S, Sundar S, Mannaert A, Vanaerschot M, Berg M, De Muylder G, Dumetz F, Cuypers B, Maes I, Domagalska M, Decuypere S, Rai K, Uranw S, Bhattarai NR, Khanal B, Prajapati VK, Sharma S, Stark O, Schönian G, De Koning HP, Settimo L, Vanhollebeke B, Roy S Ostyn B, Boelaert M, Maes L, Berriman M, Dujardin JC, Cotton JA. Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent. Elife. 2016 Mar 22;5. pii: e12613. doi: 10.7554/eLife.12613.

Lecordier L, Uzureau P, Tebabi P, Brauner J, Benghiat FS, Vanhollebeke B, Pays E. Adaptation of Trypanosoma rhodesiense to hypohaptoglobinaemic serum requires transcription of the APOL1 resistance gene in a RNA polymerase I locus. Mol Microbiol. 2015

Haubrich BA, Singha UK, Miller MB, Nes CR, Anyatonwu H, Lecordier L, Patkar P, Leaver DJ, Villalta F, Vanhollebeke B, Chaudhuri M, Nes WD. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. J Lipid Res. 2015 56(2):331-41.

Pays E, Vanhollebeke B, Uzureau P, Lecordier L, Pérez-Morga D. The molecular arms race between African trypanosomes and humans. Nat Rev Microbiol. 2014 Aug;12(8):575-84.

Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E. Mechanism of Trypanosoma brucei gambiense resistance to human serum. Nature. 2013 Sep 19;501(7467):430-4.

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13;329(5993):841-5.

Vanhollebeke B, Uzureau P, Monteyne D, Pérez-Morga D, Pays E. Cellular and molecular remodeling of the endocytic pathway during differentiation of Trypanosoma brucei bloodstream forms. Eukaryot Cell. 2010 Aug;9(8):1272-82.

Vanhollebeke B, Pays E. The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill. Mol Microbiol. 2010 May;76(4):806-14.

Lecordier L, Vanhollebeke B, Poelvoorde P, Tebabi P, Paturiaux-Hanocq F, Andris F, Lins L, Pays E. C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. PLoS Pathog. 2009 Dec;5(12):e1000685.

Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem. 2010 Jan 15;285(3):1773-80.

Pays E, Vanhollebeke B. Human innate immunity against African trypanosomes. Curr Opin Immunol. 2009 Oct;21(5):493-8.

Pays E, Vanhollebeke B. [The controversial story of the human trypanolytic factor]. Med Sci (Paris). 2008 Oct;24(10):792-3.

Pays E, Vanhollebeke B. Mutual self-defence: the trypanolytic factor story. Microbes Infect. 2008 Jul;10(9):985-9.

Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science. 2008 May 2;320(5876):677-81.

Vanhollebeke B, Lecordier L, Perez-Morga D, Amiguet-Vercher A, Pays E. Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome. J Eukaryot Microbiol. 2007 Sep-Oct;54(5):448-51.

Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, Homblé F, Vanhamme L, Tebabi P, Pays A, Poelvoorde P, Jacquet A, Brasseur R, Pays E. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science. 2005 Jul 15;309(5733):469-72.

Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P. Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. Nat Med. 2006 May;12(5):580-4.

Pays E, Vanhollebeke B, Vanhamme L, Paturiaux-Hanocq F, Nolan DP, Pérez-Morga D. The trypanolytic factor of human serum. Nat Rev Microbiol. 2006 Jun;4(6):477-86.

Vanhollebeke B, Pays E. The function of apolipoproteins L. Cell Mol Life Sci. 2006 Sep;63(17):1937-44.

Vanhollebeke B, Truc P, Poelvoorde P, Pays A, Joshi PP, Katti R, Jannin JG, Pays E. Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I. N Engl J Med. 2006 Dec 28;355(26):2752-6.

Vanhollebeke B, Nielsen MJ, Watanabe Y, Truc P, Vanhamme L, Nakajima K, Moestrup SK, Pays E. Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4118-23.