ZFIN ID: ZDB-LAB-990301-1
Moss Lab
PI/Director: Moss, Larry Gene
Co-PI / Senior
Moss, Jennifer Barnett
Contact Person: Moss, Jennifer Barnett
Email: jennifer.b.moss@duke.edu
URL: http://stedman.mc.duke.edu/modules/stedman_team/index.php?id=1
Address: Stedman Center and Division of Endocrinology Duke University - Independence Park Facility 4321 Medical Park Drive, Suite 200 Durham, NC 27704 USA
Country: United States
Phone: (919) 479-2379
Fax: (919) 477-0632
Line Designation: sc

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Our laboratory is interested in beta cell growth, development and signaling in animal models and humans, especially with relation to human diseases impacting pancreatic islet beta cells. We are members of the Duke Molecular Physiology Institute (DMPI), a new collaboration of genomics, transcriptomics, proteomics and metabolomics investigators working on many aspects of the metabolic syndrome, diabetes and obesity. Regenerating, transparent zebrafish are currently being used in our lab to test small molecules that potentiate beta cell growth in vivo. By translating positive hits into engineered tissues called vascularized islet hydrogels, we are currently developing a pipeline to identify drugs having the potential to ameliorate human diabetes. Our expertise includes the following programmatic areas:
• In vivo analysis of signal transduction pathways in the islet.
• Pancreatic islet regeneration and stem cell biology in vertebrate model systems.
• Vertebrate developmental biology and pancreas organogenesis
• Imaging and image analysis of islet cells and islet vasculature
• Small molecule potentiation of beta cell regeneration


Jacobs, H.M., Sant, K.E., Basnet, A., Williams, L.M., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere. 195:498-507
Emfinger, C.H., Welscher, A., Yan, Z., Wang, Y., Conway, H., Moss, J.B., Moss, L.G., Remedi, M.S., Nichols, C.G. (2017) Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Royal Society open science. 4:160808
Sant, K.E., Jacobs, H.M., Borofski, K.A., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 220(Pt B):807-817
Sant, K.E., Jacobs, H.M., Xu, J., Borofski, K.A., Moss, L.G., Moss, J.B., Timme-Laragy, A.R. (2016) Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model. Toxics. 4(3)
Whipps, C.M., Moss, L.G., Sisk, D.M., Murray, K.N., Tobin, D.M., and Moss, J.B. (2014) Detection of autofluorescent Mycobacterium chelonae in living zebrafish. Zebrafish. 11(1):76-82
Moss, L.G., Caplan, T.V., and Moss, J.B. (2013) Imaging Beta cell regeneration and interactions with islet vasculature in transparent adult zebrafish. Zebrafish. 10(2):249-257
Moss, J.B., Koustubhan, P., Greenman, M., Parsons, M.J., Walter, I., and Moss, L.G. (2009) Regeneration of the Pancreas in Adult Zebrafish. Diabetes. 58(8):1844-1851
Yimlamai, D., Konnikova, L., Moss, L.G., and Jay, D.G. (2005) The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis. Developmental Biology. 279(1):44-57
Walter, I., Moss, J.B., and Moss, L.G. (2002) Vital genomic markers define progenitor gut cells. Regulatory peptides. 108(1):17
diIorio, P.J., Moss, J.B., Sbrogna, J.L., Karlstrom, R.O., and Moss, L.G. (2002) Sonic hedgehog is required early in pancreatic islet development. Developmental Biology. 244(1):75-84
Amsterdam, A., Lin, S., Moss, L.G., and Hopkins, N. (1996) Requirements for green fluorescent protein detection in transgenic zebrafish embryos. Gene. 173(1 Spec No):99-103
Moss, J.B., Price, A.L., Raz, E., Driever, W., and Rosenthal, N. (1996) Green fluorescent protein marks skeletal muscle in murine cell lines and zebrafish. Gene. 173:89-98