ZFIN ID: ZDB-LAB-970909-2
Brand Lab
PI/Director: Brand, Michael
Contact Person: Brand, Michael
Email: michael.brand@biotec.tu-dresden.de
URL: http://www.biotec.tu-dresden.de/brand
Address: Technische Universitaet Dresden CRTD (Centre for Regenerative Therapies) BIOTEChnologisches Zentrum/ Fetscherstrasse 105 Dresden, 01307 Germany
Country: Germany
Phone: +49-351-458 82300
Fax: +49-351-458 82309
Line Designation: tud


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 63 genomic features


STATEMENT OF RESEARCH INTERESTS
Development of the zebrafish nervous system.


LAB MEMBERS
Grandel, Heiner Post-Doc Hans, Stefan Post-Doc Jungke, Peggy Post-Doc
Kesavan, Gokul Post-Doc Ahrendt, Reiner Graduate Student Carlos, Vanessa Graduate Student
Chekuru, Avinash Graduate Student Gözüyasli, Dilce Graduate Student Gupta, Mansi Graduate Student
Hochmann, Sarah Graduate Student Kyritsis, Nikos Graduate Student Geffarth, Michaela Research Staff
Machate, Anja Research Staff Fischer, Marika Fish Facility Staff Hopfe, Kristin Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Brunner, S., TŐkÉs, T., SzabÓ, E.R., Polanek, R., SzabÓ, I.Z., Reisz, Z., GubÁn, B.K., SzijÁrtÓ, A.L., Brand, M., Hans, S., Karsch, L., Lessmann, E., Pawelke, J., SchÜrer, M., Beyreuther, E., HideghÉty, K. (2020) Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model. Anticancer research. 40:6123-6135
Asokan, N., Daetwyler, S., Bernas, S.N., Schmied, C., Vogler, S., Lambert, K., Wobus, M., Wermke, M., Kempermann, G., Huisken, J., Brand, M., Bornhäuser, M. (2020) Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts. Scientific Reports. 10:13254
Nadar, R.A., Asokan, N., Degli Esposti, L., Curci, A., Barbanente, A., Schlatt, L., Karst, U., Iafisco, M., Margiotta, N., Brand, M., van den Beucken, J.J.J.P., Bornhäuser, M., Leeuwenburgh, S.C.G. (2020) Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model. Nanoscale. 12(25):13582-13594
Kesavan, G., Machate, A., Hans, S., Brand, M. (2020) Cell-fate plasticity, adhesion and cell sorting complementarily establish a sharp midbrain-hindbrain boundary. Development (Cambridge, England). 147(11):
Schwarzer, S., Asokan, N., Bludau, O., Kuscha, V., Kaslin, J., Hans, S. (2020) Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood. Development (Cambridge, England). 147(7):
Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
Möllmert, S., Kharlamova, M.A., Hoche, T., Taubenberger, A.V., Abuhattum, S., Kuscha, V., Kurth, T., Brand, M., Guck, J. (2019) Zebrafish Spinal Cord Repair Is Accompanied by Transient Tissue Stiffening. Biophysical journal. 118(2):448-463
Träber, N., Uhlmann, K., Girardo, S., Kesavan, G., Wagner, K., Friedrichs, J., Goswami, R., Bai, K., Brand, M., Werner, C., Balzani, D., Guck, J. (2019) Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development. Scientific Reports. 9:17031
Beyreuther, E., Brand, M., Hans, S., Hideghéty, K., Karsch, L., Leßmann, E., Schürer, M., Szabó, E.R., Pawelke, J. (2019) Feasibility of proton FLASH effect tested by zebrafish embryo irradiation. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 139:46-50
Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102
Szabó, E.R., Brand, M., Hans, S., Hideghéty, K., Karsch, L., Lessmann, E., Pawelke, J., Schürer, M., Beyreuther, E. (2018) Radiobiological effects and proton RBE determined by wildtype zebrafish embryos. PLoS One. 13:e0206879
Kesavan, G., Hammer, J., Hans, S., Brand, M. (2018) Targeted knock-in of CreER T2 in zebrafish using CRISPR/Cas9.. Cell and tissue research. 372(1):41-50
Ando, K., Shibata, E., Hans, S., Brand, M., Kawakami, A. (2017) Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance. Developmental Cell. 43(5):643-650.e3
Singh, S.P., Janjuha, S., Hartmann, T., Kayisoglu, Ö., Konantz, J., Birke, S., Murawala, P., Alfar, E.A., Murata, K., Eugster, A., Tsuji, N., Morrissey, E.R., Brand, M., Ninov, N. (2017) Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature communications. 8:664
Arulmozhivarman, G., Kräter, M., Wobus, M., Friedrichs, J., Bejestani, E.P., Müller, K., Lambert, K., Alexopoulou, D., Dahl, A., Stöter, M., Bickle, M., Shayegi, N., Hampe, J., Stölzel, F., Brand, M., von Bonin, M., Bornhäuser, M. (2017) Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells. Scientific Reports. 7:12084
Schwarzer, S., Spieß, S., Brand, M., Hans, S. (2017) Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biology Open. 6(9):1270-1278
Geurtzen, K., Vernet, A., Freidin, A., Rauner, M., Hofbauer, L.C., Schneider, J.E., Brand, M., Knopf, F. (2017) Immune suppressive and bone inhibitory effects of prednisolone in growing and regenerating zebrafish tissues. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(12):2476-2488
Kesavan, G., Chekuru, A., Machate, A., Brand, M. (2017) CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development. Frontiers in Neuroanatomy. 11:52
Kaslin, J., Kroehne, V., Ganz, J., Hans, S., Brand, M. (2017) Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration. Development (Cambridge, England). 144(8):1462-1471
Chekuru, A., Kuscha, V., Hans, S., Brand, M. (2017) Ligand-Controlled Site-Specific Recombination in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1642:87-97
Henninger, J., Santoso, B., Hans, S., Durand, E., Moore, J., Mosimann, C., Brand, M., Traver, D., Zon, L. (2017) Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nature cell biology. 19(1):17-27
Pinzon-Olejua, A., Welte, C., Chekuru, A., Bosak, V., Brand, M., Hans, S., Stuermer, C.A. (2017) Cre inducible site-specific recombination in zebrafish oligodendrocytes. Developmental dynamics : an official publication of the American Association of Anatomists. 246(1):41-49
Arulmozhivarman, G., Stöter, M., Bickle, M., Kräter, M., Wobus, M., Ehninger, G., Stölzel, F., Brand, M., Bornhäuser, M., Shayegi, N. (2016) In Vivo Chemical Screen in Zebrafish Embryos Identifies Regulators of Hematopoiesis Using a Semiautomated Imaging Assay. Journal of Biomolecular Screening. 21(9):956-64
Antos, C., Knopf, F., Brand, M. (2016) Regeneration of Organs and Appendages in Zebrafish: A Window into Underlying Control Mechanisms. Citable reviews in the life sciences. :1-17
Jungke, P., Hans, S., Gupta, M., Machate, A., Zöller, D., Brand, M. (2016) Generation of a conditional lima1a allele in zebrafish using the FLEx switch technology. Genesis (New York, N.Y. : 2000). 54(1):19-28
Hernández-Bejarano, M., Gestri, G., Spawls, L., Nieto-López, F., Picker, A., Tada, M., Brand, M., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2015) Opposing Shh and Fgf signals initiate nasotemporal patterning of the retina. Development (Cambridge, England). 142(22):3933-42
Jungke, P., Hammer, J., Hans, S., Brand, M. (2015) Isolation of Novel CreERT2-Driver Lines in Zebrafish Using an Unbiased Gene Trap Approach. PLoS One. 10:e0129072
Kizil, C., Iltzsche, A., Thomas, A.K., Bhattarai, P., Zhang, Y., Brand, M. (2015) Efficient cargo delivery into adult brain tissue using short cell-penetrating peptides. PLoS One. 10:e0124073
Kizil, C., Kyritsis, N., Brand, M. (2015) Effects of inflammation on stem cells: together they strive?. EMBO reports. 16(4):416-426
Paolini, A., Duchemin, A.L., Albadri, S., Patzel, E., Bornhorst, D., González Avalos, P., Lemke, S., Machate, A., Brand, M., Sel, S., Di Donato, V., Del Bene, F., Zolessi, F.R., Ramialison, M., Poggi, L. (2015) Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Development (Cambridge, England). 142(5):832-9
Ganz, J., Kroehne, V., Freudenreich, D., Machate, A., Geffarth, M., Braasch, I., Kaslin, J., Brand, M. (2014) Subdivisions of the adult zebrafish pallium based on molecular marker analysis. F1000Research. 3:308
Kizil, C., Küchler, B., Yan, J.J., Özhan, G., Moro, E., Argenton, F., Brand, M., Weidinger, G., Antos, C.L. (2014) Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development (Cambridge, England). 141:3529-39
Shayegi, N., Meyer, C., Lambert, K., Ehninger, G., Brand, M., and Bornhäuser, M. (2014) CXCR4 blockade and Sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. British journal of haematology. 164(3):409-13
Luz, M., Spannl-Müller, S., Özhan, G., Kagermeier-Schenk, B., Rhinn, M., Weidinger, G., and Brand, M. (2014) Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm. PLoS One. 9(1):e84922
Jungke, P. (2013) Direct Submission of CreZoo gene trap lines. ZFIN Direct Data Submission.
Weber, A., Hochmann, S., Cimalla, P., Gärtner, M., Kuscha, V., Hans, S., Geffarth, M., Kaslin, J., Koch, E., and Brand, M. (2013) Characterization of light lesion paradigms and optical coherence tomography as tools to study adult retina regeneration in zebrafish. PLoS One. 8(11):e80483
Gupta, M., and Brand, M. (2013) Identification and expression analysis of zebrafish glypicans during embryonic development. PLoS One. 8(11):e80824
de Oliveira-Carlos, V., Ganz, J., Hans, S., Kaslin, J., and Brand, M. (2013) Notch receptor expression in neurogenic regions of the adult zebrafish brain. PLoS One. 8(9):e73384
Jungke, P., Hans, S., and Brand, M. (2013) The Zebrafish CreZoo: An Easy-to-Handle Database for Novel CreERT2-Driver Lines. Zebrafish. 10(3):259-63
Bokel, C., and Brand, M. (2013) Generation and interpretation of FGF morphogen gradients in vertebrates. Current opinion in genetics & development. 23(4):415-22
Jászai, J., Graupner, S., Tanaka, E.M., Funk, R.H., Huttner, W.B., Brand, M., and Corbeil, D. (2013) Spatial Distribution of Prominin-1 (CD133) - Positive Cells within Germinative Zones of the Vertebrate Brain. PLoS One. 8(5):e63457
Kizil, C., Iltzsche, A., Kaslin, J., and Brand, M. (2013) Micromanipulation of gene expression in the adult zebrafish brain using cerebroventricular microinjection of morpholino oligonucleotides. Journal of visualized experiments : JoVE. (75):e50415
Kaslin, J., Kroehne, V., Benato, F., Argenton, F., and Brand, M. (2013) Development and specification of cerebellar stem and progenitor cells in zebrafish: from embryo to adult. Neural Development. 8(1):9
Hans, S., Irmscher, A., and Brand, M. (2013) Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development (Cambridge, England). 140(9):1936-1945
Grandel, H., and Brand, M. (2013) Comparative aspects of adult neural stem cell activity in vertebrates. Development genes and evolution. 223(1-2):131-147
Kizil, C., Kyritsis, N., Dudczig, S., Kroehne, V., Freudenreich, D., Kaslin, J., and Brand, M. (2012) Regenerative Neurogenesis from Neural Progenitor Cells Requires Injury-Induced Expression of Gata3. Developmental Cell. 23(6):1230-1237
Kyritsis, N., Kizil, C., Zocher, S., Kroehne, V., Kaslin, J., Freudenreich, D., Iltzsche, A., and Brand, M. (2012) Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain. Science (New York, N.Y.). 338(6112):1353-1356
Mahabaleshwar, H., Tarbashevich, K., Nowak, M., Brand, M., and Raz, E. (2012) beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation. Development (Cambridge, England). 139(16):2897-2902
Kizil, C., Dudczig, S., Kyritsis, N., Machate, A., Blaesche, J., Kroehne, V., and Brand, M. (2012) The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Development. 7(1):27
Kizil, C., Kaslin, J., Kroehne, V., and Brand, M. (2012) Adult neurogenesis and brain regeneration in zebrafish. Developmental Neurobiology. 72(3):429-461
Ganz, J., Kaslin, J., Freudenreich, D., Machate, A., Geffarth, M., and Brand, M. (2012) Subdivisions of the adult zebrafish subpallium by molecular marker analysis. The Journal of comparative neurology. 520(3):633-55
Hochmann, S., Kaslin, J., Hans, S., Weber, A., Machate, A., Geffarth, M., Funk, R.H., and Brand, M. (2012) Fgf Signaling is Required for Photoreceptor Maintenance in the Adult Zebrafish Retina. PLoS One. 7(1):e30365
Kroehne, V., Freudenreich, D., Hans, S., Kaslin, J., and Brand, M. (2011) Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors. Development (Cambridge, England). 138(22):4831-4841
Boldajipour, B., Doitsidou, M., Tarbashevich, K., Laguri, C., Yu, S.R., Ries, J., Dumstrei, K., Thelen, S., Dörries, J., Messerschmidt, E.M., Thelen, M., Schwille, P., Brand, M., Lortat-Jacob, H., and Raz, E. (2011) Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor. Development (Cambridge, England). 138(14):2909-2914
Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011) Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell. 20(5):713-724
Grandel, H., and Brand, M. (2011) Zebrafish limb development is triggered by a retinoic acid signal during gastrulation. Developmental dynamics : an official publication of the American Association of Anatomists. 240(5):1116-1126
Jászai, J., Fargeas, C.A., Graupner, S., Tanaka, E.M., Brand, M., Huttner, W.B., and Corbeil, D. (2011) Distinct and Conserved Prominin-1/CD133-Positive Retinal Cell Populations Identified across Species. PLoS One. 6(3):e17590
Hans, S., Freudenreich, D., Geffarth, M., Kaslin, J., Machate, A., and Brand, M. (2011) Generation of a non-leaky heat shock-inducible Cre line for conditional Cre/lox strategies in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 240(1):108-115
Kizil, C., and Brand, M. (2011) Cerebroventricular Microinjection (CVMI) into Adult Zebrafish Brain Is an Efficient Misexpression Method for Forebrain Ventricular Cells. PLoS One. 6(11):e27395
Winkler, S., Gscheidel, N., and Brand, M. (2011) Mutant Generation in Vertebrate Model Organisms by TILLING. Methods in molecular biology (Clifton, N.J.). 770:475-504
Ganz, J., Kaslin, J., Hochmann, S., Freudenreich, D., and Brand, M. (2010) Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon. Glia. 58(11):1345-1363
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., Winkler, S., Brand, M., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource, MPI Dresden, and Hubrecht laboratory. ZFIN Direct Data Submission.
Rohner, N., Bercsényi, M., Orbán, L., Kolanczyk, M.E., Linke, D., Brand, M., Nüsslein-Volhard, C., and Harris, M.P. (2009) Duplication of fgfr1 Permits Fgf Signaling to Serve as a Target for Selection during Domestication. Current biology : CB. 19(19):1642-1647
Picker, A., Cavodeassi, F., Machate, A., Bernauer, S., Hans, S., Abe, G., Kawakami, K., Wilson, S.W., and Brand, M. (2009) Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. PLoS Biology. 7(10):e1000214
Yu, S.R., Burkhardt, M., Nowak, M., Ries, J., Petrášek, Z., Scholpp, S., Schwille, P., and Brand, M. (2009) Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature. 461(7263):533-536
Ries, J., Yu, S.R., Burkhardt, M., Brand, M., and Schwille, P. (2009) Modular scanning FCS quantifies receptor-ligand interactions in living multicellular organisms. Nature Methods. 6(9):643-645
Kaslin, J., Ganz, J., Geffarth, M., Grandel, H., Hans, S., and Brand, M. (2009) Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(19):6142-6153
Rhinn, M., Lun, K., Ahrendt, R., Geffarth, M., and Brand, M. (2009) Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Development. 4:12
Hans, S., Kaslin, J., Freudenreich, D., and Brand, M. (2009) Temporally-controlled site-specific recombination in zebrafish. PLoS One. 4(2):e4640
Picker, A., Roellig, D., Pourquié, O., Oates, A.C., and Brand, M. (2009) Tissue micromanipulation in zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 546:153-172
Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M., and Zerial, M. (2008) The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell. 133(3):486-497
Ochi, H., Hans, S., and Westerfield, M. (2008) Smarcd3 regulates the timing of zebrafish myogenesis onset. The Journal of biological chemistry. 283(6):3529-3536
Funfak, A., Brösing, A., Brand, M., and Köhler, J.M. (2007) Micro fluid segment technique for screening and development studies on Danio rerio embryos. Lab on a Chip. 7(9):1132-1138
Wendl, T., Adzic, D., Schoenebeck, J.J., Scholpp, S., Brand, M., Yelon, D., and Rohr, K.B. (2007) Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development (Cambridge, England). 134(15):2871-2879
Hans, S., and Westerfield, M. (2007) Changes in retinoic acid signaling alter otic patterning. Development (Cambridge, England). 134(13):2449-2458
Caneparo, L., Huang, Y.L., Staudt, N., Tada, M., Ahrendt, R., Kazanskaya, O., Niehrs, C., and Houart, C. (2007) Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes & Development. 21(4):465-480
Hans, S., Christison, J., Liu, D., and Westerfield, M. (2007) Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Developmental Biology. 7(1):5
Erickson, T., Scholpp, S., Brand, M., Moens, C.B., and Waskiewicz, A. Jan (2007) Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Developmental Biology. 301(2):504-517
Grandel, H., Kaslin, J., Ganz, J., Wenzel, I., and Brand, M. (2006) Neural stem cells and neurogenesis in the adult zebrafish brain: Origin, proliferation dynamics, migration and cell fate. Developmental Biology. 295(1):263-277
Reim, G., and Brand, M. (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development (Cambridge, England). 133(14):2757-2770
Scholpp, S., Wolf, O., Brand, M., and Lumsden, A. (2006) Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development (Cambridge, England). 133(5):855-864
Rhinn, M., Picker, A., and Brand, M. (2006) Global and local mechanisms of forebrain and midbrain patterning. Current opinion in neurobiology. 16(1):5-12
Norton, W.H., Ledin, J., Grandel, H., and Neumann, C.J. (2005) HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development. Development (Cambridge, England). 132(22):4963-4973
Picker, A., and Brand, M. (2005) Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina. Development (Cambridge, England). 132(22):4951-4962
Langenberg, T., and Brand, M. (2005) Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary. Development (Cambridge, England). 132(14):3209-3216
Rhinn, M., Lun, K., Luz, M., Werner, M., and Brand, M. (2005) Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development (Cambridge, England). 132(6):1261-1272
Siekmann, A.F., and Brand, M. (2005) Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic Hedgehog signaling. Developmental dynamics : an official publication of the American Association of Anatomists. 232(2):498-505
Raible, F., and Brand, M. (2004) Divide et Impera – the midbrain–hindbrain boundary and its organizer. Trends in neurosciences. 27(12):727-734
Scholpp, S., and Brand, M. (2004) Endocytosis controls spreading and effective signaling range of fgf8 protein. Current biology : CB. 14(20):1834-1841
Hans, S., Liu, D., and Westerfield, M. (2004) Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development (Cambridge, England). 131(20):5091-5102
Hans, S., Scheer, N., Riedl, I., Von Weizsacker, E., Blader, P., and Campos-Ortega, J.A. (2004) her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Development (Cambridge, England). 131(12):2957-2969
Scholpp, S., Groth, C., Lohs, C., Lardelli, M., and Brand, M. (2004) Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Development genes and evolution. 214(6):285-295
Rhinn, M., Lun, K., Werner, M., Simeone, A., and Brand, M. (2004) Isolation and expression of the homeobox gene Gbx1 during mouse development. Developmental dynamics : an official publication of the American Association of Anatomists. 2:334-339
Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y., and Brand, M. (2004) The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Developmental Cell. 6(1):91-101
Jászai, J., Reifers, F., Picker, A., Langenberg, T., and Brand, M. (2003) Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity. Development (Cambridge, England). 130(26):6611-6623
Langenberg, T., Brand, M., and Cooper, M.S. (2003) Imaging brain development and organogenesis in zebrafish using immobilized embryonic explants. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):464-474
Scholpp, S. and Brand, M. (2003) Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):313-322
Scholpp, S., Lohs, C., and Brand, M. (2003) Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon. Development (Cambridge, England). 130(20):4881-4893
Rhinn, M., Lun, K., Amores, A., Yan, Y.-L., Postlethwait, J.H., and Brand, M. (2003) Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling. ZFIN Direct Data Submission.
Gajewski, M., Sieger, D., Alt, B., Leve, C., Hans, S., Wolff, C., Rohr, K.B., and Tautz, D. (2003) Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish. Development (Cambridge, England). 130(18):4269-4278
Rhinn, M., Lun, K., Amores, A., Yan, Y.-L., Postlethwait, J.H., and Brand, M. (2003) Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling. Mechanisms of Development. 120(8):919-936
Léger, S. and Brand, M. (2002) Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning. Mechanisms of Development. 119(1):91-108
Hans, S. and Campos-Ortega, J.A. (2002) On the organisation of the regulatory region of the zebrafish deltaD gene. Development (Cambridge, England). 129(20):4773-4784
Wendl, T., Lun, K., Mione, M., Favor, J., Brand, M., Wilson, S.W., and Rohr, K.B. (2002) pax2.1 is required for the development of thyroid follicles in zebrafish. Development (Cambridge, England). 129(15):3751-3760
Klisa, C., Bayley, P., Lyons, D.A., Nüsslein-Volhard, C., Clarke, J.D.W., Brand, M., and Wilson, S.W. (2002) Identification and characterization of novel zebrafish brain development mutants by large-scale mutagenesis screening. Developmental Biology. 247(2):447
Picker, A., Scholpp, S., Bohli, H., Takeda, H., and Brand, M. (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development (Cambridge, England). 129(13):3227-3239
Cerdà, J., Gründ, C., Franke, W.W., and Brand, M. (2002) Molecular characterization of calymmin, a novel notochord sheath-associated extracellular matrix protein in the zebrafish embryo. Developmental dynamics : an official publication of the American Association of Anatomists. 224(2):200-209
Grandel, H., Lun, K., Rauch, G.J., Rhinn, M., Piotrowski, T., Houart, C., Sordino, P., Küchler, A.M., Schulte-Merker, S., Geisler, R., Holder, N., Wilson, S.W., and Brand, M. (2002) Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development (Cambridge, England). 129(12):2851-2865
Burgess, S., Reim, G., Chen, W., Hopkins, N., and Brand, M. (2002) The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Development (Cambridge, England). 129(4):905-916
Reim, G. and Brand, M. (2002) spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development. Development (Cambridge, England). 129(4):917-933
Wilson, S.W., Brand, M., and Eisen, J.S. (2002) Patterning the zebrafish central nervous system. Results and problems in cell differentiation. 40:181-215
Raible, F. and Brand, M. (2001) Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development. Mechanisms of Development. 107(1-2):105-117
Araki, I., and Brand, M. (2001) Morpholino-induced knockdown of fgf8 efficiently phenocopies the acerebellar (ace) phenotype. Genesis (New York, N.Y. : 2000). 30(3):157-159
Scholpp, S. and Brand, M. (2001) Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain–hindbrain boundary development. Genesis (New York, N.Y. : 2000). 30(3):129-133
Fürthauer, M., Reifers, F., Brand, M., Thisse, B., and Thisse, C. (2001) sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development (Cambridge, England). 128(12):2175-2186
Scheer, N., Groth, A., Hans, S., and Campos-Ortega, J.A. (2001) An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development (Cambridge, England). 128(7):1099-1107
Rhinn, M. and Brand, M. (2001) The midbrain-hindbrain boundary organizer. Current opinion in neurobiology. 11(1):34-42
Reifers, F., Adams, J., Mason, I.J., Schulte-Merker, S., and Brand, M. (2000) Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mechanisms of Development. 99(1-2):39-49
Adamska, M., Leger, S., Brand, M., Hadrys, T., Braun, T., and Bober, E. (2000) Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace. Mechanisms of Development. 97(1-2):161-165
Grandel, H., Draper, B.W., and Schulte-Merker, S. (2000) dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling. Development (Cambridge, England). 127(19):4169-4178
Shanmugalingam, S., Houart, C., Picker, A., Reifers, F., Macdonald, R., Barth, A., Griffin, K., Brand, M., and Wilson, S.W. (2000) Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development (Cambridge, England). 127(12):2549-2561
Majumdar, A., Lun, K., Brand, M., and Drummond, I.A. (2000) Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia. Development (Cambridge, England). 127(10):2089-2098
Brand, M. (2000) Abstracts of papers presented at the 2000 meeting on zebrafish development & genetics, April 26-April 30, 2000. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory. :358 p
Brand, M., Lun, K., Reifers, F., Thisse, B., Thisse, C., Amores, A., Yan, Y.-L., and Postlethwait, J. (2000) Subdivision of the early zebrafish neural primordium in response to posteriorizing signals. The European journal of neuroscience. 12:60
Reifers, F., Walsh, E.C., Léger, S., Stainier, D.Y.R., and Brand, M. (2000) Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar). Development (Cambridge, England). 127(2):225-235
Neumann, C.J., Grandel, H., Gaffield, W., Schulte-Merker, S., Nüsslein-Volhard, C. (1999) Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity. Development (Cambridge, England). 126(21):4817-4826
Leimer, U., Lun, K., Romig, H., Walter, J., Grunberg, J., Brand, M., and Haass, C. (1999) Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry. 38(41):13602-13609
Picker, A., Brennan, C., Reifers, F., Clarke, J.D., Holder, N., and Brand, M. (1999) Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Development (Cambridge, England). 126(13):2967-2978
Brand, M. and Granato, M. (1999) Keeping and raising zebrafish. In Zebrafish: A Practical Approach, S. Schulte-Merker and C. Nüsslein-Volhard, eds. IRL Press.
Grandel, H. and Schulte-Merker, S. (1998) The development of the paired fins in the zebrafish (Danio rerio). Mechanisms of Development. 79:99-120
Cerdà, J., Conrad, M., Markl, J., Brand, M., and Herrmann, H. (1998) Zebrafish vimentin: molecular characterization, assembly properties and developmental expression. European journal of cell biology. 77:175-187
Lun, K. and Brand, M. (1998) A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development (Cambridge, England). 125:3049-3062
Pfeffer, P.L., Gerster, T., Lun, K., Brand, M., and Busslinger, M. (1998) Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development (Cambridge, England). 125:3063-3074
Reifers, F., Bohli, H., Walsh, E.C., Crossley, P.H., Stainier, D.Y., and Brand, M. (1998) Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development (Cambridge, England). 125:2381-2395
Brand, M. (1998) Genetic analysis of early development of a vertebrate nervous system in the zebrafish, Danio rerio. Zool. Anal. Complex Syst.. 101(4):345-364
Wilson, S.W., C. Brennan, Macdonald, R., M. Brand, and N. Holder (1997) Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundaries. Cell and tissue research. 290(2):189-196
Macdonald, R., Scholes, J., Strähle, U., Brennan, C., Holder, N., Brand, M., and Wilson, S.W. (1997) The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development (Cambridge, England). 124(12):2397-2408
Brand, M. (1997) Zebrafish Development and Genetics. In Encyclopedia of Neuroscience, B.S.G. Adelman, ed., Amsterdam, NY: Elsevier Science.
Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development (Cambridge, England). 123:179-190
Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development (Cambridge, England). 123:229-239
Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:143-151
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., van Eeden, F.J., Granato, M., Brand, M., Furutani-Seiki, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development (Cambridge, England). 123:95-102
Heisenberg, C.P., Brand, M., Jiang, Y.J., Warga, R.M., Beuchle, D., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development (Cambridge, England). 123:191-203
Jiang, Y.J., Brand, M., Heisenberg, C.P., Beuchle, D., Furutani-Seiki, M., Kelsh, R.N., Warga, R.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development (Cambridge, England). 123:205-216
Kane, D.A., Hammerschmidt, M., Mullins, M.C., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish epiboly mutants. Development (Cambridge, England). 123:47-55
Kane, D.A., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Heisenberg-, C.P., Jiang, Y.J., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish early arrest mutants. Development (Cambridge, England). 123:57-66
Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438
Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389
Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., and Nüsslein-Volhard, C. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (Cambridge, England). 123:81-93
Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development (Cambridge, England). 123:103-115
Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R.N., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:391-398
Piotrowski, T., Schilling, T.F., Brand, M., Jiang, Y.J., Heisenberg, C.P., Beuchle, D., Grandel, H., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. II. Anterior arches and cartilage differentiation. Development (Cambridge, England). 123:345-356
Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319
Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki-, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (Cambridge, England). 123:153-164
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:255-262
Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254
Haffter, P., Odenthal, J., Mullins, M.C., Lin, S., Farrell, M.J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Hopkins, N., and Nüsslein-Volhard, C. (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Development genes and evolution. 206(4):260-276
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