ZFIN ID: ZDB-LAB-970408-13
Kimmel Lab
PI/Director: Kimmel, Charles B.
Contact Person: Kimmel, Charles B.
Email: kimmel@uoneuro.uoregon.edu
URL: http://www.neuro.uoregon.edu/kimmel/KLab_web/klab.html
Address: Institute of Neuroscience 1254 University of Oregon Eugene OR 97403-1254 USA
Country: United States
Phone: (541) 346-4506
Fax: (541) 346-4548
Line Designation: b

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Our lab focuses on the cellular and genetic mechanisms that control the shaping of skull cartilages and bones during development, and on how development changes during evolution to produce the marvelous diversity that we observe the skulls in different kinds of animals. We use teleost fish for these studies. We take advantage of zebrafish as a model system for development and genetics, of stickleback as a model for evolutionary biology and evo devo, and of teleosts more generally, the most species rich of all vertebrate groups, for their outstanding phenotypic variation.

Chicas-Cruz, Adela Research Staff Dowd, John Research Staff Kimmel, Reida J. Research Staff
Ullmann, Bonnie Research Staff Walker, Charline Research Staff

Nichols, J.T., Blanco-Sánchez, B., Brooks, E.P., Parthasarathy, R., Dowd, J., Subramanian, A., Nachtrab, G., Poss, K.D., Schilling, T.F., Kimmel, C.B. (2016) Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development (Cambridge, England). 143(23):4430-4440
Talbot, J.C., Nichols, J.T., Yan, Y.L., Leonard, I.F., BreMiller, R.A., Amacher, S.L., Postlethwait, J.H., Kimmel, C.B. (2016) Pharyngeal morphogenesis requires fras1-itga8- dependent epithelial-mesenchymal interaction. Developmental Biology. 416(1):136-48
Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813
Delaurier, A., Huycke, T.R., Nichols, J.T., Swartz, M.E., Larsen, A., Walker, C., Dowd, J., Pan, L., Moens, C.B., and Kimmel, C.B. (2014) Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Developmental Biology. 385(2):189-99
Jemielita, M., Taormina, M.J., Delaurier, A., Kimmel, C.B., and Parthasarathy, R. (2013) Comparing phototoxicity during the development of a zebrafish craniofacial bone using confocal and light sheet fluorescence microscopy techniques. Journal of biophotonics. 6(11-12):920-8
Nichols, J.T., Pan, L., Moens, C.B., and Kimmel, C.B. (2013) barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development (Cambridge, England). 140(13):2765-2775
Sasaki, M.M., Nichols, J.T., and Kimmel, C.B. (2013) edn1 and hand2 Interact in Early Regulation of Pharyngeal Arch Outgrowth during Zebrafish Development. PLoS One. 8(6):e67522
Eames, B.F., Delaurier, A., Ullmann, B., Huycke, T.R., Nichols, J.T., Dowd, J., McFadden, M., Sasaki, M.M., and Kimmel, C.B. (2013) FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Developmental Biology. 13(1):23
Hinits, Y., Pan, L., Walker, C., Dowd, J., Moens, C.B., and Hughes, S.M. (2012) Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Developmental Biology. 369(2):199-210
Talbot, J.C., Walker, M.B., Carney, T.J., Huycke, T.R., Yan, Y.L., Bremiller, R.A., Gai, L., Delaurier, A., Postlethwait, J.H., Hammerschmidt, M., and Kimmel, C.B. (2012) fras1 shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development. Development (Cambridge, England). 139(15):2804-2813
Huycke, T.R., Eames, B.F., and Kimmel, C.B. (2012) Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development (Cambridge, England). 139(13):2371-2380
Delaurier, A., Nakamura, Y., Braasch, I., Khanna, V., Kato, H., Wakitani, S., Postlethwait, J.H., and Kimmel, C.B. (2012) Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Developmental Biology. 12(1):16
Eames, B.F., Yan, Y.L., Swartz, M.E., Levic, D.S., Knapik, E.W., Postlethwait, J.H., and Kimmel, C.B. (2011) Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation. PLoS Genetics. 7(8):e1002246
Delaurier, A., Eames, B.F., Blanco-Sánchez, B., Peng, G., He, X., Swartz, M.E., Ullmann, B., Westerfield, M., and Kimmel, C.B. (2010) Zebrafish sp7:EGFP: A transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis (New York, N.Y. : 2000). 48(8):505-511
Talbot, J.C., Johnson, S.L., and Kimmel, C.B. (2010) hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development (Cambridge, England). 137(15):2507-2517
Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genetics. 6(4):e1000907
Kimmel, C.B., Delaurier, A., Ullmann, B., Dowd, J., and McFadden, M. (2010) Modes of developmental outgrowth and shaping of a craniofacial bone in zebrafish. PLoS One. 5(3):e9475
Walker, C., Walsh, G.S., and Moens, C. (2009) Making gynogenetic diploid zebrafish by early pressure. Journal of visualized experiments : JoVE. (28)
Kimmel, C.B., and Eberhart, J.K. (2008) The midline, oral ectoderm, and the arch-0 problem. Integrative and Comparative Biology. 48(5):668-680
Laue, K., Daujat, S., Crump, J.G., Plaster, N., Roehl, H.H., Tübingen 2000 Screen Consortium, Kimmel, C.B., Schneider, R., and Hammerschmidt, M. (2008) The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development (Cambridge, England). 135(11):1935-1946
Eberhart, J.K., He, X., Swartz, M.E., Yan, Y.L., Song, H., Boling, T.C., Kunerth, A.K., Walker, M.B., Kimmel, C.B., and Postlethwait, J.H. (2008) MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nature Genetics. 40(3):290-298
Kimmel, C.B., Walker, M.B., and Miller, C.T. (2007) Morphing the hyomandibular skeleton in development and evolution. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):609-624
Miller, C.T., Swartz, M.E., Khuu, P.A., Walker, M.B., Eberhart, J.K., and Kimmel, C.B. (2007) mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish. Developmental Biology. 308(1):144-157
Walker, M.B., Miller, C.T., Swartz, M.E., Eberhart, J.K., and Kimmel, C.B. (2007) phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish. Developmental Biology. 304(1):194-207
Walker, M., and Kimmel, C. (2007) A two-color acid-free cartilage and bone stain for zebrafish larvae. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 82(1):23-28
Muyskens, J.B., and Kimmel, C.B. (2007) Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer. Mechanisms of Development. 124(1):35-42
Crump, J.G., Swartz, M.E., Eberhart, J.K., and Kimmel, C.B. (2006) Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development (Cambridge, England). 133(14):2661-9
Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B. (2006) Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Developmental Biology. 295(1):194-205
Eberhart, J.K., Swartz, M.E., Crump, J.G., and Kimmel, C.B. (2006) Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development (Cambridge, England). 133(6):1069-1077
Maves, L., and Kimmel, C.B. (2005) Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Developmental Biology. 285(2):593-605
Yan, Y.L., Willoughby, J., Liu, D., Crump, J.G., Wilson, C., Miller, C.T., Singer, A., Kimmel, C., Westerfield, M., and Postlethwait, J.H. (2005) A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development (Cambridge, England). 132(5):1069-1083
Wiellette, E., Grinblat, Y., Austen, M., Hirsinger, E., Amsterdam, A., Walker, C., Westerfield, M., and Sive, H. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis (New York, N.Y. : 2000). 40(4):231-240
Crump, J.G., Maves, L., Lawson, N.D., Weinstein, B.M., and Kimmel, C.B. (2004) An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development (Cambridge, England). 131(22):5703-5716
Crump, J.G., Swartz, M.E., and Kimmel, C.B. (2004) An Integrin-Dependent Role of Pouch Endoderm in Hyoid Cartilage Development. PLoS Biology. 2(9):E244
Miller, C.T., Maves, L., and Kimmel, C.B. (2004) moz regulates Hox expression and pharyngeal segmental identity in zebrafish. Development (Cambridge, England). 131(10):2443-2461
Draper, B.W., Stock, D.W., and Kimmel, C.B. (2003) Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Development (Cambridge, England). 130(19):4639-4654
Kimmel, C.B., Ullmann, B., Walker, M., Miller, C.T., and Crump, J.G. (2003) Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. Development (Cambridge, England). 130(7):1339-1351
Miller, C.T., Yelon, D., Stainier, D.Y., and Kimmel, C.B. (2003) Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development (Cambridge, England). 130(7):1353-1365
Glickman, N.S., Kimmel, C.B., Jones, M.A., and Adams, R.J. (2003) Shaping the zebrafish notochord. Development (Cambridge, England). 130(5):873-887
Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P.A., Amsterdam, A., Chung, B.-C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., and Postlethwait, J.H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis. Development (Cambridge, England). 129(21):5065-5079
Henry, C.A., Urban, M.K., Dill, K.K., Merlie, J.P., Page, M.F., Kimmel, C.B., and Amacher, S.L. (2002) Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries. Development (Cambridge, England). 129(15):3693-3704
Maves, L., Jackman, W., and Kimmel, C.B. (2002) FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development (Cambridge, England). 129:3825-3837
Maves, L. and Kimmel, C.B. (2002) Dual roles for FGF signaling in promoting zebrafish hindbrain development. Developmental Biology. 247(2):480-481
Amacher, S.L., Draper, B.W., Summers, B.R., and Kimmel, C.B. (2002) The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate. Development (Cambridge, England). 129(14):3311-3323
Sehnert, A.J., Huq, A., Weinstein, B.M., Walker, C., Fishman, M., and Stainier, D.Y. (2002) Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nature Genetics. 31(1):106-110
Singer, A., Perlman, H., Yan, Y.-L., Walker, C., Corley-Smith, G., Brandhorst, B., and Postlethwait, J. (2002) Sex-specific recombination rates in zebrafish (Danio rerio). Genetics. 160(2):649-657
Topczewski, J., Sepich, D.S., Myers, D.C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., and Solnica-Krezel, L. (2001) The zebrafish glypican Knypek controls cell polarity during gastrulation movements of convergent extension. Developmental Cell. 1(2):251-264
Draper, B.W., Morcos, P.A., and Kimmel, C.B. (2001) Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: A quantifiable method for gene knockdown. Genesis (New York, N.Y. : 2000). 30(3):154-156
Kimmel, C.B., Miller, C.T., and Keynes, R.J. (2001) Neural crest patterning and the evolution of the jaw. Journal of anatomy. 199(1-2):105-120
Miller, C.T. and Kimmel, C.B. (2001) Morpholino phenocopies of endothelin 1 (sucker) and other anterior arch class mutations. Genesis (New York, N.Y. : 2000). 30(3):186-187
Kimmel, C.B., Miller, C.T., and Moens, C.B. (2001) Specification and morphogenesis of the zebrafish larval head skeleton. Developmental Biology. 233(2):239-257
Cooke, J.E., Moens, C.B., Roth, L.W., Durbin, L., Shiomi, K., Brennan, C., Kimmel, C.B., Wilson, S.W., and Holder, N. (2001) Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain. Development (Cambridge, England). 128(4):571-580
Jensen, A.M., Walker, C., and Westerfield, M. (2001) mosaic eyes: a zebrafish gene required in pigmented epithelium for apical localization of retinal cell division and lamination. Development (Cambridge, England). 128(1):95-105
Miller, C.T., Schilling, T.F., Lee, K., Parker, J., and Kimmel, C.B. (2000) sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development. Development (Cambridge, England). 127(17):3815-3828
Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C.B., and Moens, C.B. (2000) lazarus is a novel pbx gene that globally mediates Hox gene function in zebrafish. Molecular Cell. 6(2):255-267
Draper, B. W., Phillips, J.B., Stock, D.W., and Kimmel, C.B. (1999) FGF signaling and mesodermal patterning in the zebrafish embryo. Developmental Biology. 210(1):151-180
Corley-Smith, G.E., Brandhorst, B.P., Walker, C., and Postlethwait, J.H. (1999) Production of haploid and diploid androgenetic zebrafish (including methodology for delayed in vitro fertilization).. Methods in cell biology. 59:45-60
Walker, C. (1999) Haploid screens and gamma-ray mutagenesis. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:43-70
Kimmel, C.B., Miller, C.T., Kruse, G., Ullmann, B., BreMiller, R.A., Larison, K.D., and Snyder, H.C. (1998) The shaping of the pharnygeal cartilages during early development of the zebrafish. Developmental Biology. 203:245-263
Griffin, K.J.P., Amacher, S.L., Kimmel, C.B., and Kimelman, D. (1998) Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development (Cambridge, England). 125:3379-3388
Yamamoto, A., Amacher, S.L., Kim, S.-H., Geissert, D., Kimmel, C.B., and De Robertis, E.M. (1998) Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm. Development (Cambridge, England). 125:3389-3397
Amacher, S.L. and Kimmel, C.B. (1998) Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm. Development (Cambridge, England). 125:1397-1406
Moens, C.B., Cordes, S.P., Giorgianni, M.W., Barsh, G.S., and Kimmel, C.B, (1998) Equivalence in the genetic control of hindbrain segmentation in fish and mouse. Development (Cambridge, England). 125:381-391
Prince, V.E., Moens, C.B., Kimmel, C.B., and Ho, R.K. (1998) Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene valentino. Development (Cambridge, England). 125:393-406
Amacher, S.L. and Kimmel, C.B. (1998) Does vertebrate segmentation utilize pair-rules?. Developmental Biology. 198:201
Talbot, W.S., Egan, E.S., Gates, M.A., Walker, C., Ullmann, B., Neuhauss, S.C.F., Kimmel, C.B., and Postlethwait, J.H. (1998) Genetic analysis of chromosomal rearrangements in the cyclops region of the zebrafish genome. Genetics. 148:373-380
Schilling, T.F. and Kimmel, C.B. (1997) Musculoskeletal patterning in the pharyngeal segments of the zebrafish embryo. Development (Cambridge, England). 124(15):2945-2960
Beattie, C.E., Hatta, K., Halpern, M.E., Liu, H., Eisen, J.S., and Kimmel, C.B. (1997) Temporal separation in the specification of primary and secondary motoneurons in zebrafish. Developmental Biology. 187(2):171-182
Halpern, M.E., Hatta, K., Amacher, S.L., Talbot, W.S., Yan, Y.-L., Thisse, B., Thisse, C., Postlethwait, J.H., and Kimmel, C.B. (1997) Genetic interactions in zebrafish midline development. Developmental Biology. 187(2):154-170
Chandrasekhar, A., Moens, C.B., Warren, J.T., Kimmel, C.B., and Kuwada, J.Y. (1997) Development of branchiomotor neurons in zebrafish. Development (Cambridge, England). 124(13):2633-2644
Melby, A.E., Kimelman, D., and Kimmel, C.B. (1997) Spatial regulation of floating head expression in the developing notochord. Developmental dynamics : an official publication of the American Association of Anatomists. 209(2):156-165
Cooper, M.S. and Kimmel, C.B. (1997) Morphogenetic cell behaviors during early teleost development. In Motion Analysis in Living Cells. Soll-D-R., ed., New York: Wiley-Liss.
Fritz, A., Rozowski, M., Walker, C., and Westerfield, M. (1996) Identification of selected gamma-ray induced deficiencies in zebrafish using multiplex polymerase chain reaction. Genetics. 144(4):1735-1745
Moens, C.B., Yan, Y.L., Appel, B., Force, A.G., and Kimmel, C.B. (1996) valentino, a zebrafish gene required for normal hindbrain segmentation. Development (Cambridge, England). 122:3981-3990
Melby, A.E., Warga, R.M., and Kimmel, C.B. (1996) Specification of cell fates at the dorsal margin of the zebrafish gastrula. Development (Cambridge, England). 122:2225-2237
Schilling, T.F., Walker, C., and Kimmel, C.B. (1996) The chinless mutation and neural crest cell interactions in zebrafish jaw development. Development (Cambridge, England). 122:1417-1426
Halpern, M.E., Thisse, C., Ho, R.K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E.S., Postlethwait, J.H., and Kimmel, C.B. (1995) Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development (Cambridge, England). 121:4257-4264
Kauffman, E.J., Gestl, E.E., Kim, D.J., Walker, C., Hite, J.M., Yan, G., Rogan, P.K., Johnson, S.L., and Cheng, K.C. (1995) Microsatellite-centromere mapping in the zebrafish (Danio rerio). Genomics. 30:337-341
Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D. (1995) A homeobox gene essential for zebrafish notochord development. Nature. 378:150-157
Kimmel, C.B., Ballard, W.W., Kimmel, S.R., Ullmann, B., and Schilling, T.F. (1995) Stages of embryonic development of the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 203:253-310
Johnson, S.L., Africa, D., Walker, C., and Weston, J.A. (1995) Genetic control of adult pigment stripe development in zebrafish. Developmental Biology. 167:27-33
Postlethwait, J., Johnson, S., Midson, C.N., Talbot, W.S., Gates, M., Ballenger, E.W., Africa, D., Andrews, R., Carl, T., Eisen, J.S., Horne, S., Kimmel, C.B., Hutchinson, M., Johnson, M., and Rodriguez, A. (1994) A genetic linkage map for the zebrafish. Science (New York, N.Y.). 264:699-703
Schulte-Merker, S., van Eeden, F.J.M., Halpern, M.E., Kimmel, C.B., and Nüsslein-Volhard, C. (1994) no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development (Cambridge, England). 120:1009-1015
Hatta, K., Püschel, A.W., and Kimmel, C.B. (1994) Midline signaling in the primordium of the zebrafish anterior central nervous system. Proc. Natl. Acad. Sci. USA. 91:2061-2065
Schilling, T.F. and Kimmel, C.B. (1994) Segment and cell type lineage restrictions during pharyngeal arch development in the zebrafish embryo. Development (Cambridge, England). 120:483-494
Kimmel, C.B., Warga, R.M., and Kane, D.A. (1994) Cell cycles and clonal strings during formation of the zebrafish central nervous system. Development (Cambridge, England). 120:265-276
Halpern, M.E., Ho, R.K., Walker, C., and Kimmel, C.B. (1993) Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell. 75:99-111
Kane, D.A. and Kimmel, C.B. (1993) The zebrafish midblastula transition. Development (Cambridge, England). 119:447-456
Ho, R.K. and Kimmel, C.B. (1993) Commitment of cell fate in the early zebrafish embryo. Science (New York, N.Y.). 261:109-111
Hatta, K. and Kimmel, C.B. (1993) Midline structures and central nervous system coordinates in zebrafish. Pers. Dev. Neurobiol.. 1:257-268
Kimmel, C.B. (1993) Patterning the brain of the zebrafish embryo. Annual review of neuroscience. 16:707-732
Kimmel, C.B., Molven, A., Ellis, T.J., Hatta, K., Ho, R.K., Kane, D.A., Schilling, T.F., Walker, C., and Warga, R.M. (1993) Developmental and mutational analysis of body pattern formation: the zebrafish model. In Physiological and Biochemical Aspects of Fish Development, Walther-B-T. and Fyhn-H-J., eds., Bergen, Norway: University of Bergen Press. :22-29
Kane, D.A., Warga, R.M., and Kimmel, C.B. (1992) Mitotic domains in the early embryo of the zebrafish. Nature. 360:735-737
Felsenfeld, A.L., Curry, M., and Kimmel, C.B. (1991) The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneer cells. Developmental Biology. 148:23-30
Hatta, K., BreMiller, R.A., Westerfield, M., and Kimmel, C.B. (1991) Diversity of expression of engrailed-like antigens in zebrafish. Development (Cambridge, England). 112:821-832
Hatta, K., Kimmel, C.B., Ho, R.K., and Walker, C. (1991) The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature. 350:339-341
Kimmel, C.B., Hatta, K., and Eisen, J.S. (1991) Genetic control of primary neuronal development in zebrafish. Development (Cambridge, England). (Suppl.) 2:47-57
Kimmel, C.B., Kane, D.A., and Ho, R.K. (1991) Lineage specification during early embryonic development of the zebrafish. In Cell-Cell Interactions in Early Development, J. Gerhart, ed., Wiley, N.Y.. :203-225
Kimmel, C.B., Schilling, T.F., and Hatta, K. (1991) Patterning of body segments of the zebrafish embryo. Current topics in developmental biology. 25:77-110
Schilling, T.F., Walker, C., and Kimmel, C.B. (1991) Mutations that disrupt the development of cranial neural crest cells in the zebrafish. Soc. Neurosci. Abstr.. 17:924
Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B. (1990) Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression. Science (New York, N.Y.). 250:802-805
Metcalfe, W.K., Myers, P.Z., Trevarrow, B., Bass, M.B., and Kimmel, C.B. (1990) Primary neurons that express the L2-HNK-1 carbohydrate during early development in the zebrafish. Development (Cambridge, England). 110:491-504
Molven, A., Wright, C.V.E., BreMiller, R., De Robertis, E.M., and Kimmel, C.B. (1990) Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan. Development (Cambridge, England). 109:279-288
Westerfield, M., Liu, D.W., Kimmel, C.B., and Walker, C. (1990) Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors. Neuron. 4:867-874
Trevarrow, B., Marks, D.L., and Kimmel, C.B. (1990) Organization of hindbrain segments in the zebrafish embryo. Neuron. 4:669-679
Kimmel, C.B., Hatta, K., and Metcalfe, W.K. (1990) Early axonal contacts during development of an identified dendrite in the brain of the zebrafish. Neuron. 4:535-545
Kimmel, C.B., Warga, R.M., and Schilling, T.F. (1990) Origin and organization of the zebrafish fate map. Development (Cambridge, England). 108:581-594
Warga, R.M. and Kimmel, C.B. (1990) Cell movements during epiboly and gastrulation in zebrafish. Development (Cambridge, England). 108:569-580
Felsenfeld, A.L., Walker, C., Westerfield, M., Kimmel, C., and Streisinger, G. (1990) Mutations affecting skeletal muscle myofibril structure in the zebrafish. Development (Cambridge, England). 108:443-459
Kimmel, C.B. (1990) Embryonic origins of segmented nervous systems. In Molecular Approaches Toward Supracellular Phenomena. Roth-S., ed., University of Pennsylvania Press. :137-174
Kimmel, C.B. and Westerfield, M. (1990) Primary neurons of the zebrafish. In Signal and Sense, G.M. Edelman, W.E. Gall, and M.W. Cowan, eds., New York: Wiley-Liss. :561-588
Schilling, T.F., Hatta, K., Walker, C., and Kimmel, C.B. (1990) Jaw muscles do not differentiate in a zebrafish mutant that lacks neural crest derived jaw cartilage. The Journal of cell biology. 111:238A
Kimmel, C.B. (1989) Genetics and early development of zebrafish. Trends in genetics : TIG. 5:283-288
Kimmel, C.B., Kane, D.A., Walker, C., Warga, R.M., and Rothman, M.B. (1989) A mutation that changes cell movement and cell fate in the zebrafish embryo. Nature. 337:358-362
Schilling, T.F., Warga, R.M., and Kimmel, C.B. (1989) Cranial muscles and motoneurons that innervate them originate from the same axial levels in the zebrafish. Soc. Neurosci. Abstr.. 15:810
Streisinger, G., Coale, F., Taggart, C., Walker, C., and Grunwald, D.J. (1989) Clonal origin of cells in the pigmented retina of the zebrafish eye. Developmental Biology. 131(1):60-69
Hanneman, E., Trevarrow, B., Metcalfe, W.K., Kimmel, C.B., and Westerfield, M. (1988) Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo. Development (Cambridge, England). 103:49-58
Grunwald, D.J., Kimmel, C.B., Westerfield, M., Walker, C., and Streisinger, G. (1988) A neural degeneration mutation that spares primary neurons in the zebrafish. Developmental Biology. 126:115-128
Kimmel, C.B. and Warga, R.M. (1988) Cell lineage and developmental potential of cells in the zebrafish embryo. Trends in genetics : TIG. 4:68-74
Kimmel, C.B., Sepich, D.S., and Trevarrow, B. (1988) Development of segmentation in zebrafish. Development (Cambridge, England). 104:197-208
Kimmel, C.B. and Warga, R.M. (1987) Indeterminate cell lineage of the zebrafish embryo. Developmental Biology. 124:269-280
Kimmel, C.B. and Warga, R.M. (1987) Cell lineages generating axial muscle in the zebrafish embryo. Nature. 327:234-237
Kimmel, C.B. (1987) Developmental Neurobiology. In Developmental Biology. N. Holder and V. Walbot, eds.. :518-550
Kimmel, C.B. and Warga, R.M. (1987) Cell lineages and movements in the formation of the zebrafish embryonic axis. Soc. Neurosci. Abstr.. 13:891
Myers, P.Z., Eisen, J.S., and Kimmel, C.B. (1987) The early development of Rohon-Beard neurons in embryonic zebrafish. Soc. Neurosci. Abstr.. 13:5
Trevarrow, W.W., Metcalfe, W.K., Kimmel, C.B., and Marks, D. (1987) The zebrafish hindbrain is segmentally organized. Soc. Neurosci. Abstr.. 13:255
Westerfield, M., Kimmel, C.B., and Walker, C. (1987) Normal pathfinding by pioneer motor growth cones in mutant zebrafish lacking functional acetylcholine receptors. Soc. Neurosci. Abstr.. 13:5
Mendelson, B. and Kimmel, C.B. (1986) Identified vertebrate neurons that differ in axonal projection develop together. Developmental Biology. 118:309-313
Metcalfe, W.K., Mendelson, B., and Kimmel, C.B. (1986) Segmental homologies among reticulospinal neurons in the hindbrain of the zebrafish larva. The Journal of comparative neurology. 251:147-159
Streisinger, G., Singer, F., Walker, C., Knauber, D., and Dower, N. (1986) Segregation analysis and gene-centromere distances in zebrafish. Genetics. 112:311-319
Kimmel, C.B. and Warga, R.M. (1986) Tissue specific cell lineages originate in the gastrula of the zebrafish. Science (New York, N.Y.). 231:356-368
Westerfield, M., Eisen, J.S., Myers, P.Z., McMurray, J.V., and Kimmel, C.B. (1986) Early neurogenesis in the zebrafish. Proc. Int. Union Physiol. Sci.. 16:20
Kimmel, C.B., Metcalfe, W.K., and Schabtach, E. (1985) T reticular interneurons: a class of serially repeating cells in the zebrafish hindbrain. The Journal of comparative neurology. 233:365-376
Metcalfe, W.K., Kimmel, C.B., and Schabtach, E. (1985) Anatomy of the posterior lateral line system in young larvae of the zebrafish. The Journal of comparative neurology. 233:377-389
Kimmel, C.B. and Law, R.D. (1985) Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells. Developmental Biology. 108:78-85
Kimmel, C.B. and Law, R.D. (1985) Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer. Developmental Biology. 108:86-93
Kimmel, C.B. and Law, R.D. (1985) Cell lineage of zebrafish blastomeres: III. Clonal analyses of the blastula and gastrula stages. Developmental Biology. 108(1):94-101
Grunwald, D.J., Streisinger, G., and Walker, C. (1985) Clonal origins of cells in the zebrafish eye. Journal of cellular biochemistry. (Suppl.) 9B:270
Kimmel, C.B. and Warga, R.M. (1985) Embryonic lineages and migrations of cells during epiboly and axis formation in the zebrafish. Journal of cellular biochemistry. (Suppl.) 9B:272
Kimmel, C.B., Grunwald, D.J., Walker, C., Westerfield, M., and Streisinger, G. (1985) Neuronal degeneration mutations that spare primary neurons in the zebrafish. Soc. Neurosci. Abstr.. 11:647
Metcalfe, W.K., Kimmel, C.B., and Mendelson, B. (1985) Segmental patterning of morphological types of reticulospinal neurons in larval zebrafish. Soc. Neurosci. Abstr.. 11:604
Kimmel, C.B., Warga, R., and Law, R.D. (1984) Cellular lineages forming the zebrafish nervous system. Soc. Neurosci. Abstr.. 10:1044
Chakrabarti, S., Streisinger, G., Singer, F., and Walker, C. (1983) Frequency of gamma-ray induced specific locus and recessive lethal mutations in mature germ cells of the zebrafish, Brachydanio rerio. Genetics. 103:109-124
Walker, C. and Streisinger, G. (1983) Induction of mutations by gamma-rays in pregonial germ cells of zebrafish embryos. Genetics. 103:125-136
Prugh, J.I.P., Kimmel, C.B., and Metcalfe, W.K. (1982) Noninvasive recording of the Mauthner neuron action potential in larval zebrafish (Brachydanio rerio). The Journal of experimental biology. 101:83-92
Kimmel, C.B., Powell, S.L., and Kimmel, R.J. (1982) Specific reduction of development of the Mauthner neuron lateral dendrite after otic capsule ablation in Brachydanio rerio. Developmental Biology. 91:468-473
Kimmel, C.B., Powell, S.L., and Metcalfe, W.K. (1982) Brain neurons which project to the spinal cord in young larvae of the zebrafish. The Journal of comparative neurology. 205:112-127
Golin, J., Grunwald, D.J., Singer, F., Walker, C., and Streisinger, G. (1982) Ethyl nitroso urea induced germline mutations in zebrafish Brachydanio-rerio. Genetics. 100:S27
Kimmel, C.B. (1982) Development of synapses on the Mauthner neuron. Trends in neurosciences. 5:47-50
Kimmel, C.B. (1982) Reticulospinal and vestibulospinal neurons in the young larva of a teleost fish, Brachydanio rerio. Progress in brain research. 57:1-23
Kimmel, C.B., Metcalfe, W.K., and Schabtach, E. (1982) Reticular interneurons with T-shaped axons in embryos of the zebrafish. Soc. Neurosci. Abstr.. 8:764
Metcalfe, W.K. and Kimmel, C.B. (1982) Three types of posterior lateral line efferent neurons in larval zebrafish. Soc. Neurosci. Abstr.. 8:763
Streisinger, G., Walker, C., Dower, N., Knauber, D., and Singer, F. (1981) Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature. 291(5813):293-296
Kimmel, C.B., Sessions, S.K., and Kimmel, R.J. (1981) Morphogenesis and synaptogenesis of the zebrafish Mauthner neuron. The Journal of comparative neurology. 198:101-120
Eaton, R.C. and Kimmel, C.B. (1980) Directional sensitivity of the Mauthner cell system to vibrational stimulation in zebrafish (Brachydanio rerio) larvae. J. Comp. Physiol. A. 140:337-342
Kimmel, C.B. and Powell, S.L. (1980) Brain neurons that project to the spinal cord in young larvae of the zebrafish. Soc. Neurosci. Abstr.. 6:628
Kimmel, C.B., Eaton, R.C., and Powell, S.L. (1980) Decreased fast-start performance of zebrafish (Brachydanio rerio) larvae lacking Mauthner neurons. J. Comp. Physiol. A. 140:343-350
Walker-Durchanek, R.C. (1980) Induction of germ line mutations by irradiation of zebrafish embryos. Master's Thesis.
Kimmel, C.B., Sessions, S.K., and Kimmel, R.J. (1979) Target recognition in neurogenesis: formation of the Mauthner axon cap. Proc. Natl. Acad. Sci. USA. 76(9):4691-4694
Kimmel, C.B., Sessions, S.K., and Kimmel, R.J. (1978) Radiosensitivity and time of origin of Mauthner neuron in the zebra fish. Developmental Biology. 62(2):526-529
Eaton, R.C., Kimmel, C.B., and Sessions, S.K. (1978) The Mauthner system mediates directional responses to local vibrational stimuli. Soc. Neurosci. Abstr.. 4:361
Kimmel, C.B. and Model, P. (1978) Developmental studies of the Mauthner cell. In Neurobiology of the Mauthner Cell. Faber-D-S. and Korn-H., eds. New York: Raven Press. :183-220
Kimmel, C.B., Powell, S.L., and Eaton, R.C. (1978) Does the Mauthner cell mediate unique behavior?. Soc. Neurosci. Abstr.. 4:362
Eaton, R.C., Farley, R.D., Kimmel, C.B., and Schabtach, E. (1977) Functional development in the Mauthner cell system of embryos and larvae of the zebrafish. Journal of neurobiology. 8(2):151-172
Eaton, R.C. and Kimmel, C.B. (1977) Function of the Mauthner cell in the developing zebra fish. Proc. Int. Union Physiol. Sci.. 13:203
Kimmel, C.B. and Eaton, R.C. (1976) Development of the Mauthner cell. In Simpler Networks and Behaviour. Fentress-J-C. ed., Sunderland, MA: Sinauer Associates Inc.. :186-202
Kimmel, C.B., Patterson, J., and Kimmel, R.J. (1974) The development and behavioral characteristics of the startle response in the zebra fish. Dev. Psychobiol.. 7(1):47-60
Kimmel, C.B. (1972) Mauthner axons in living fish larvae. Developmental Biology. 27:272-275