ZFIN Lab: Ninov Lab

ZFIN ID: ZDB-LAB-181219-1

Ninov Lab

PI/Director:	Ninov, Nikolay
Contact Person:	Ninov, Nikolay
Email:	nikolay.ninov@tu-dresden.de
URL:	http://www.crt-dresden.de/research/research-groups/core-groups/crtd-core-groups/b-cell-biology-and-regeneration/
Address:	CRTD / Center for Regenerative Therapies Dresden - Cluster of Excellence, Fetscherstraße 105 01307 Dresden
Country:	Germany
Phone:	+49 (0)351 458 82314
Fax:	+49 351 458-82059
Line Designation:	tud

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 6 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Akhtar, Nadeem Graduate Student	Delgadillo Silva, Luis Fernando Graduate Student	Janjuha, Sharan Graduate Student
Kamel, Margrit Graduate Student	Birke, Sarah Technical Staff	Palme, Silvia Administrative Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Delgadillo-Silva, L.F., Akhtar, M.N., Taşöz, E., Ninov, N. (2021) Simultaneous Calcium Imaging and Glucose Stimulation in Living Zebrafish to Investigate In Vivo β-Cell Function. Journal of visualized experiments : JoVE. (175):

Mousavy Gharavy, S.N., Owen, B.M., Millership, S.J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N.H.F., Jacobson, D.A., Dickerson, M.T., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D.J., Ninov, N., Gadue, P.J., Cardenas-Diaz, F.L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M., Rutter, G.A. (2021) Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia. 64(4):850-864

Gillotay, P., Shankar, M., Haerlingen, B., Sema Elif, E., Pozo-Morales, M., Garteizgogeascoa, I., Reinhardt, S., Kränkel, A., Bläsche, J., Petzold, A., Ninov, N., Kesavan, G., Lange, C., Brand, M., Lefort, A., Libert, F., Detours, V., Costagliola, S., Singh, S.P. (2020) Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland. EMBO reports. 21(12):e50612

Deville, S.S., Delgadillo Silva, L.F., Vehlow, A., Cordes, N. (2020) c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair. International Journal of Molecular Sciences. 21(19):

Singh, S.P., Ninov, N. (2020) Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in Zebrafish. Methods in molecular biology (Clifton, N.J.). 2128:159-179

Salem, V., Silva, L.D., Suba, K., Georgiadou, E., Neda Mousavy Gharavy, S., Akhtar, N., Martin-Alonso, A., Gaboriau, D.C.A., Rothery, S.M., Stylianides, T., Carrat, G., Pullen, T.J., Singh, S.P., Hodson, D.J., Leclerc, I., Shapiro, A.M.J., Marchetti, P., Briant, L.J.B., Distaso, W., Ninov, N., Rutter, G.A. (2019) Leader β-cells coordinate Ca²⁺ dynamics across pancreatic islets in vivo. Nature metabolism. 1:615-629

Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15

Delgadillo-Silva, L.F., Tsakmaki, A., Akhtar, N., Franklin, Z.J., Konantz, J., Bewick, G.A., Ninov, N. (2019) Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Disease models & mechanisms. 12(1):

Singh, S.P., Janjuha, S., Chaudhuri, S., Reinhardt, S., Kränkel, A., Dietz, S., Eugster, A., Bilgin, H., Korkmaz, S., Zararsız, G., Ninov, N., Reid, J.E. (2018) Machine learning based classification of cells into chronological stages using single-cell transcriptomics. Scientific Reports. 8:17156

Janjuha, S., Pal Singh, S., Ninov, N. (2018) Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets. Journal of visualized experiments : JoVE. (137)

Spanjaard, B., Hu, B., Mitic, N., Olivares-Chauvet, P., Janjuha, S., Ninov, N., Junker, J.P. (2018) Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars. Nature Biotechnology. 36(5):469-473

Janjuha, S., Singh, S.P., Tsakmaki, A., Mousavy-Gharavy, N., Murawala, P., Konantz, J., Birke, S., Hodson, D.J., Rutter, G., Bewick, G., Ninov, N.N. (2018) Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLIFE. 7

So, J., Khaliq, M., Evason, K., Ninov, N., Martin, B.L., Stainier, D.Y.R., Shin, D. (2017) Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating Notch activity. Hepatology (Baltimore, Md.). 67(6):2352-2366

Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630

Singh, S.P., Janjuha, S., Hartmann, T., Kayisoglu, Ö., Konantz, J., Birke, S., Murawala, P., Alfar, E.A., Murata, K., Eugster, A., Tsuji, N., Morrissey, E.R., Brand, M., Ninov, N. (2017) Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature communications. 8:664

Kamel, M., Ninov, N. (2017) Catching new targets in metabolic disease with a zebrafish. Current opinion in pharmacology. 37:41-50

Ahmed Alfar, E., Kirova, D., Konantz, J., Birke, S., Mansfeld, J., Ninov, N. (2017) Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity. Scientific Reports. 7:3994

Ninov, N., Yun, M.H. (2015) Current advances in tissue repair and regeneration: the future is bright. Regeneration (Oxford, England). 2:84-91

Tsuji, N., Ninov, N., Delawary, M., Osman, S., Roh, A.S., Gut, P., Stainier, D.Y. (2014) Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation. PLoS One. 9:e104112

Choi, T.Y., Ninov, N., Stainier, D.Y., and Shin, D. (2014) Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes after Near Total Loss of Hepatocytes in Zebrafish. Gastroenterology. 146(3):776-88

Ninov, N., Hesselson, D., Gut, P., Zhou, A., Fidelin, K., and Stainier, D.Y. (2013) Metabolic Regulation of Cellular Plasticity in the Pancreas. Current biology : CB. 23(13):1242-50

Ninov, N., Borius, M., and Stainier, D.Y. (2012) Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors. Development (Cambridge, England). 139(9):1557-1567

Delous, M., Yin, C., Shin, D., Ninov, N., Debrito Carten, J., Pan, L., Ma, T.P., Farber, S.A., Moens, C.B., and Stainier, D.Y. (2012) sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development. PLoS Genetics. 8(6):e1002754