ZFIN ID: ZDB-LAB-180522-1
Masino Lab
PI/Director: Masino, Mark A.
Contact Person: Masino, Mark A.
Email: masino@umn.edu
URL: http://neurosci.umn.edu/bio/department-of-neuroscience/mark-masino
Address: Department of Neuroscience University of Minnesota 3-145 Jackson Hall Minneapolis, MN 55455
Country: United States
Phone: 612-625-4412
Fax: 612-626-5009
Line Designation: umn

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Most rhythmic motor patterns in animals, including breathing, chewing, limbed locomotion, and undulatory swimming are programmed in part by neural circuits called central pattern generators. These pattern generators often have, at their core, rhythmically active neurons or neural networks. The study of these pattern generators has yielded insight not only into the origins of rhythmic activity, but also into the functioning and modulation of neural networks in general. My primary interest is to understand how spinal circuits are structurally and functionally organized to generate different rhythmic motor patterns. In vertebrates, neural circuits are located in spinal cord and mediate rhythmic movements by the activation of spinal motor neurons via premotor interneurons. Therefore, different movements must, in part, be determined by the differences in activity of the spinal premotor interneurons.

Wahlstrom-Helgren, Sarah Post-Doc Montgomery, Jacob Research Staff Peck, Jack Research Staff
Vanpelt, Kayce Research Staff

Montgomery, J.E., Wahlstrom-Helgren, S., Vanpelt, K.T., Masino, M.A. (2021) Repetitive optogenetic stimulation of glutamatergic neurons: An alternative to NMDA treatment for generating locomotor activity in spinalized zebrafish larvae. Physiological Reports. 9:e14774
Koleilat, A., Dugdale, J.A., Christenson, T.A., Bellah, J.L., Lambert, A.M., Masino, M.A., Ekker, S.C., Schimmenti, L.A. (2020) L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1. Disease models & mechanisms. 13(11):
Wahlstrom-Helgren, S., Montgomery, J.E., Vanpelt, K.T., Biltz, S.L., Peck, J.H., Masino, M.A. (2019) Glutamate receptor subtypes differentially contribute to optogenetically-activated swimming in spinally-transected zebrafish larvae. Journal of neurophysiology. 122(6):2414-2426
Tye, M., Masino, M.A. (2019) Dietary Contaminants and Their Effects on Zebrafish Embryos. Toxics. 7(3):
Montgomery, J.E., Wahlstrom-Helgren, S., Wiggin, T.D., Corwin, B.M., Lillesaar, C., Masino, M.A. (2018) Intraspinal serotonergic signaling suppresses locomotor activity in larval zebrafish. Developmental Neurobiology.
Tye, M.T., Montgomery, J.E., Hobbs, M.R., Vanpelt, K.T., Masino, M.A. (2018) An Adult Zebrafish Diet Contaminated with Chromium Reduces the Viability of Progeny. Zebrafish. 15(2):179-187
Montgomery, J.E., Wiggin, T.D., Rivera-Perez, L.M., Lillesaar, C., Masino, M.A. (2016) Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish. Developmental Neurobiology. 76(6):673-87
Li, X., Montgomery, J., Cheng, W., Noh, J.H., Hyde, D.R., and Li, L. (2012) Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish. PLoS One. 7(7):e40508
Bailey, T.J., Fossum, S.L., Fimbel, S.M., Montgomery, J.E., and Hyde, D.R. (2010) The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Experimental Eye Research. 91(5):601-612
Thummel, R., Enright, J.M., Kassen, S.C., Montgomery, J.E., Bailey, T.J., and Hyde, D.R. (2010) Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration. Experimental Eye Research. 90(5):572-582
Montgomery, J.E., Parsons, M.J., and Hyde, D.R. (2010) A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. The Journal of comparative neurology. 518(6):800-814
Thummel, R., Kassen, S.C., Enright, J.M., Nelson, C.M., Montgomery, J.E., and Hyde, D.R. (2008) Characterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration. Experimental Eye Research. 87(5):433-444
Burket, C.T., Montgomery, J.E., Thummel, R., Kassen, S.C., Lafave, M.C., Langenau, D.M., Zon, L.I., and Hyde, D.R. (2008) Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Research. 17(2):265-279
Thummel, R., Kassen, S.C., Montgomery, J.E., Enright, J.M., and Hyde, D.R. (2008) Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retina. Developmental Neurobiology. 68(3):392-408
Kassen, S.C., Ramanan, V., Montgomery, J.E., Burket, C.T., Liu, C.G., Vihtelic, T.S., and Hyde, D.R. (2007) Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish. Developmental Neurobiology. 67(8):1009-1031
Fimbel, S.M., Montgomery, J.E., Burket, C.T., and Hyde, D.R. (2007) Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(7):1712-1724