ZFIN ID: ZDB-LAB-170210-1
Yanchun Yan Lab
PI/Director: Yan, Yanchun
Contact Person: Yan, Yanchun
Email: Yanyanchun@caas.cn
Address: Laboratory of Bichemical and Molecular Biology No.12 Zhongguancun South St., Haidian District Beijing, 100081 P.R.China
Country: China
Phone: 86-10-82109685
Fax: 86-10-82106609
Line Designation: None assigned


The overall goal of our lab is to utilize zebrafish, especially zebrafish embryo, as a basis for the development of (a) mechanistic biomarkers (b) techniques for extrapolation of toxicological effects across endpoints and chemicals, and (c) ecological risk assessments. To achieve this, a combination of whole organism endpoints, transcriptomics and proteomics, approaches is being used to (a) identify new molecular biomarkers of exposure to environmental pollutants,Further research takes advantage of the well characterized zebrafish (Danio rerio) genome, to identify transcriptome and proteome level changes associated with zebrafish exposure to the same suite of environmental pollutants. These data are being used to identify relevant molecular changes that could (a) serve as diagnostic markers for various types of environmental pollutants exposure and (b) begin to inform a systems-level characterization of the responses to those exposures.

Lv, Peng Graduate Student

Lv, P., Ma, D., Gao, S., Zhang, Y., Bae, Y.K., Liang, G., Gao, S., Choi, J.H., Kim, C.H., Wang, L., Liu, F. (2020) Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 15(3):749-760
Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696
Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
Liu, L., Zhu, H., Yan, Y., Lv, P., Wu, W. (2018) Toxicity Evaluation and Biomarker Selection with Validated Reference Gene in Embryonic Zebrafish Exposed to Mitoxantrone. International Journal of Molecular Sciences. 19(11)
Zhang, J., Liu, L., Ren, L., Feng, W., Lv, P., Wu, W., Yan, Y. (2017) The single and joint toxicity effects of chlorpyrifos and beta-cypermethrin in zebrafish (Danio rerio) early life stages. Journal of hazardous materials. 334:121-131
Liu, L., Yan, Y., Wang, J., Wu, W., Xu, L. (2016) Generation of mt:egfp transgenic zebrafish biosensor for the detection of aquatic zinc and cadmium. Environmental toxicology and chemistry. 35(8):2066-73
Yu, K., Li, G., Feng, W., Liu, L., Zhang, J., Wu, W., Xu, L., Yan, Y. (2015) Chlorpyrifos is estrogenic and alters embryonic hatching, cell proliferation and apoptosis in zebrafish. Chemico-biological interactions. 239:26-33
Liu, L., Xu, Y., Xu, L., Wang, J., Wu, W., Xu, L., Yan, Y. (2015) Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 167C:183-189