ZFIN ID: ZDB-LAB-161220-3
Klopocki Lab
PI/Director: Klopocki, Eva
Contact Person: Liedtke, Daniel
Email: eva.klopocki@uni-wuerzburg.de
URL: http://www.humgen.biozentrum.uni-wuerzburg.de/forschung/ag_prof_klopocki/
Address: Institute for Human Genetics University of Würzburg Biozentrum, Am Hubland 97074 Würzburg Germany
Country: Germany
Phone: +49-931-31-89779
Fax: +49-931-31-87398
Line Designation: wue

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We are interested in investigation of disease causing human mutations leading to Craniosynostosis and extremity malformations. For functional investigation we use the zebrafish to model specific genetic alterations and to analyze molecular or developmental consequences in vivo.

Liedtke, Daniel Post-Doc Blümel, Rabea Graduate Student Knaup, Sabine Technical Staff

Bauer, B., Liedtke, D., Jarzina, S., Stammler, E., Kreisel, K., Lalomia, V., Diefenbacher, M., Klopocki, E., Mally, A. (2021) Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing. Toxicology letters. 344:69-81
Liedtke, D., Hofmann, C., Jakob, F., Klopocki, E., Graser, S. (2020) Tissue-Nonspecific Alkaline Phosphatase-A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease. Biomolecules. 10(12):
Ohlebusch, B., Borst, A., Frankenbach, T., Klopocki, E., Jakob, F., Liedtke, D., Graser, S. (2020) Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development. Scientific Reports. 10:13321
Liedtke, D., Orth, M., Meissler, M., Geuer, S., Knaup, S., Köblitz, I., Klopocki, E. (2019) ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects. Scientific Reports. 9:13383
Blümel, R., Zink, M., Klopocki, E., Liedtke, D. (2019) On the traces of tcf12: Investigation of the gene expression pattern during development and cranial suture patterning in zebrafish (Danio rerio). PLoS One. 14:e0218286
Brodehl, A., Rezazadeh, S., Williams, T., Munsie, N.M., Liedtke, D., Oh, T., Ferrier, R., Shen, Y., Jones, S.J.M., Stiegler, A.L., Boggon, T.J., Duff, H.J., Friedman, J.M., Gibson, W.T., FORGE Canada Consortium, Childs, S.J., Gerull, B. (2019) Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy. Translational research : the journal of laboratory and clinical medicine. 208:15-29
Arndt, A.K., Schafer, S., Drenckhahn, J.D., Sabeh, M.K., Plovie, E.R., Caliebe, A., Klopocki, E., Musso, G., Werdich, A.A., Kalwa, H., Heinig, M., Padera, R.F., Wassilew, K., Bluhm, J., Harnack, C., Martitz, J., Barton, P.J., Greutmann, M., Berger, F., Hubner, N., Siebert, R., Kramer, H.H., Cook, S.A., MacRae, C.A., and Klaassen, S. (2013) Fine Mapping of the 1p36 Deletion Syndrome Identifies Mutation of PRDM16 as a Cause of Cardiomyopathy. American journal of human genetics. 93(1):67-77
Doelken, S.C., Köhler, S., Mungall, C.J., Gkoutos, G.V., Ruef, B.J., Smith, C., Smedley, D., Bauer, S., Klopocki, E., Schofield, P.N., Westerfield, M., Robinson, P.N., and Lewis, S.E. (2013) Phenotypic overlap in the contribution of individual genes to CNV pathogenicity revealed by cross-species computational analysis of single-gene mutations in humans, mice and zebrafish. Disease models & mechanisms. 6(2):358-372
Klopocki, E., Lohan, S., Doelken, S.C., Stricker, S., Ockeloen, C.W., Thiele de Aguiar R.S., Lezirovitz, K., Netto, R.C.M., Jamsheer, A., Shah, H., Kurth, I., Habenicht, R., Warman, M., Devriendt, K., Kordass, U., Hempel, M., Rajabm, A., Mäkitie, O., Naveed, M., Radhakrishna, U., Antonarakis, S.E., Horn, D., and Mundlos, S. (2012) Duplications of BHLHA9 are associated with ectrodactyly and tibia hemimelia inherited in non-Mendelian fashion. Journal of Medical Genetics. 49(2):119-125
Liedtke, D., Erhard, I., and Schartl, M. (2011) snail gene expression in the medaka, Oryzias latipes. Gene expression patterns : GEP. 11(3-4):181-189
Braasch, I., Liedtke, D., Volff, J.N., and Schartl, M. (2009) Pigmentary function and evolution of tyrp1 gene duplicates in fish. Pigment cell & melanoma research. 22(6):839-850
Kleinschmidt, M.A., Wagner, T.U., Liedtke, D., Spahr, S., Samans, B., and Gaubatz, S. (2009) Lin9 is required for mitosis and cell survival during early zebrafish development. The Journal of biological chemistry. 284(19):13119-13127
Herpin, A., Fischer, P., Liedtke, D., Kluever, N., Neuner, C., Raz, E., and Schartl, M. (2008) Sequential SDF1a and b-induced mobility guides Medaka PGC migration. Developmental Biology. 320(2):319-327
Liedtke, D., and Winkler, C. (2008) Midkine-b regulates cell specification at the neural plate border in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(1):62-74
Elmasri, H., Liedtke, D., Lücking, G., Volff, J.N., Gessler, M., and Winkler, C. (2004) her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes). Gene expression patterns : GEP. 4(5):553-559