ZFIN ID: ZDB-LAB-150205-4
Seok-Hyung Kim Lab
PI/Director: Kim, Seok-Hyung
Contact Person: Kim, Seok-Hyung
Email: kims@musc.edu
URL: http://https://education.musc.edu/MUSCApps/facultydirectory/Kim-Seok-hyung
Address: Department of Medicine, Division of Nephrology Medical University of South Carolina Drug Discovery Building, DD510 70 President Street Charleston,SC 29425
Country: United States
Phone: 843-876-2338,
Fax: 843-876-2179
Line Designation: muz


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 19 genomic features


STATEMENT OF RESEARCH INTERESTS
Our lab focuses on Genetic diseases involved in inborn errors of metabolism affecting post-developmental liver disorders. We have identified 19 novel zebrafish mutants showing post-developmental liver defects such as NAFLD, hepatomegaly or hepatic necrosis via forward genetic screening. These mutants will be used to understand mechanism of disease progression and to identify novel therapeutic small molecules.


LAB MEMBERS
Park, Ki-Hoon Post-Doc


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Sagar, A., Arif, E., Solanki, A.K., Srivastava, P., Janech, M.G., Kim, S.H., Lipschutz, J.H., Kwon, S.H., Ashish, ., Nihalani, D. (2017) Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function. Scientific Reports. 7:12047
Lobo, G.P., Fulmer, D., Guo, L., Zuo, X., Dang, Y., Kim, S.H., Su, Y., George, K., Obert, E., Fogelgren, B., Nihalani, D., Norris, R.A., Rohrer, B., Lipschutz, J.H. (2017) The exocyst is required for photoreceptor ciliogenesis and retinal development. The Journal of biological chemistry. 292(36):14814-14826
Baek, J.I., Kwon, S.H., Zuo, X., Kwon, S.Y., Kim, S.H., Lipschutz, J.H. (2016) Dynamin Binding Protein (Tuba) deficiency inhibits ciliogenesis and nephrogenesis in vitro and in vivo. The Journal of biological chemistry. 291(16):8632-43
Nishioka, T., Arima, N., Kano, K., Hama, K., Itai, E., Yukiura, H., Kise, R., Inoue, A., Kim, S.H., Solnica-Krezel, L., Moolenaar, W.H., Chun, J., Aoki, J. (2016) ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. Scientific Reports. 6:23433
Samuel, A., Rubinstein, A.M., Azar, T.T., Ben-Moshe Livne, Z., Kim, S.H., Inbal, A. (2016) Six3 regulates optic nerve development via multiple mechanisms. Scientific Reports. 6:20267
Kim, S.H., Wu, S.Y., Baek, J.I., Choi, S.Y., Su, Y., Flynn, C.R., Gamse, J.T., Ess, K.C., Hardiman, G., Lipschutz, J.H., Abumrad, N.N., Rockey, D.C. (2015) A Post-Developmental Genetic Screen for Zebrafish Models of Inherited Liver Disease. PLoS One. 10:e0125980
Choi, S.Y., Baek, J.I., Zuo, X., Kim, S.H., Dunaief, J.L., Lipschutz, J.H. (2015) Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish. Investigative ophthalmology & visual science. 56:3361-3370
Dubrulle, J., Jordan, B.M., Akhmetova, L., Farrell, J.A., Kim, S.H., Solnica-Krezel, L., Schier, A.F. (2015) Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. eLIFE. 4
Targoff, K.L., Colombo, S., George, V., Schell, T., Kim, S.H., Solnica-Krezel, L., and Yelon, D. (2013) Nkx genes are essential for maintenance of ventricular identity. Development (Cambridge, England). 140(20):4203-4213
Kim, S.H., Kowalski, M.L., Carson, R.P., Bridges, L.R., and Ess, K.C. (2013) Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Disease models & mechanisms. 6(4):925-33
Kim, S.H., Scott, S.A., Bennett, M.J., Carson, R.P., Fessel, J., Brown, H.A., and Ess, K.C. (2013) Multi-organ Abnormalities and mTORC1 Activation in Zebrafish Model of Multiple Acyl-CoA Dehydrogenase Deficiency. PLoS Genetics. 9(6):e1003563
Boglev, Y., Badrock, A.P., Trotter, A.J., Du, Q., Richardson, E.J., Parslow, A.C., Markmiller, S.J., Hall, N.E., de Jong-Curtain, T.A., Ng, A.Y., Verkade, H., Ober, E.A., Field, H.A., Shin, D., Shin, C.H., Hannan, K.M., Hannan, R.D., Pearson, R.B., Kim, S.H., Ess, K.C., Lieschke, G.J., Stainier, D.Y., and Heath, J.K. (2013) Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genetics. 9(2):e1002379
Shin, J., Padmanabhan, A., de Groh, E.D., Lee, J.S., Haidar, S., Dahlberg, S., Guo, F., He, S., Wolman, M.A., Granato, M., Lawson, N.D., Wolfe, S.A., Kim, S.H., Solnica-Krezel, L., Kanki, J.P., Ligon, K.L., Epstein, J.A., and Look, A.T. (2012) Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease models & mechanisms. 5(6):881-894
Kim, S.H., Speirs, C.K., Solnica-Krezel, L., and Ess, K.C. (2011) Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Disease models & mechanisms. 4(2):255-267
Williams, C., Kim, S.H., Ni, T.T., Mitchell, L., Ro, H., Penn, J.S., Baldwin, S.H., Solnica-Krezel, L., and Zhong, T.P. (2010) Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Developmental Biology. 341(1):196-204
Speirs, C.K., Jernigan, K.K., Kim, S.H., Cha, Y.I., Lin, F., Sepich, D.S., DuBois, R.N., Lee, E., and Solnica-Krezel, L. (2010) Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development (Cambridge, England). 137(8):1327-1337
Kim, S., Kim, S.H., Kim, H., Chung, A.Y., Cha, Y.I., Kim, C.H., Huh, T.L., and Park, H.C. (2008) Frizzled 8a function is required for oligodendrocyte development in the zebrafish spinal cord. Developmental dynamics : an official publication of the American Association of Anatomists. 237(11):3324-3331
Prober, D.A., Zimmerman, S., Myers, B.R., McDermott, B.M. Jr, Kim, S.H., Caron, S., Rihel, J., Solnica-Krezel, L., Julius, D., Hudspeth, A.J., and Schier, A.F. (2008) Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(40):10102-10110
Inbal, A., Kim, S.H., Shin, J., and Solnica-Krezel, L. (2007) Six3 represses nodal activity to establish early brain asymmetry in zebrafish. Neuron. 55(3):407-415
Kim, H.S., Shin, J., Kim, S.H., Chun, H.S., Kim, J.D., Kim, Y.S., Kim, M.J., Rhee, M., Yeo, S.Y., and Huh, T.L. (2007) Eye field requires the function of Sfrp1 as a Wnt antagonist. Neuroscience letters. 414(1):26-29
Cha, Y.I., Kim, S.H., Sepich, D., Buchanan, F.G., Solnica-Krezel, L., and Dubois, R.N. (2006) Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes & Development. 20(1):77-86
Cha, Y.I., Kim, S.H., Solnica-Krezel, L., and Dubois, R.N. (2005) Cyclooxygenase-1 signaling is required for vascular tube formation during development. Developmental Biology. 282(1):274-283
Yoo, K.W., Kim, C.H., Park, H.C., Kim, S.H., Kim, H.S., Hong, S.K., Han, S., Rhee, M., and Huh, T.L. (2003) Characterization and expression of a presomitic mesoderm-specific mespo gene in zebrafish. Development genes and evolution. 213(4):203-206
Suh, Y.H., Shin, Y.K., Kook, M.C., Oh, K.I., Park, W.S., Kim, S.H., Lee, I.S., Park, H.J., Huh, T.L., and Park, S.H. (2003) Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. Gene. 307:63-76
Kim, S.-H., Shin, J., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Han, S., Rhee, M., Kim, C.-H., Chitnis, A.B., and Huh, T.-L. (2002) Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development (Cambridge, England). 129(19):4443-4455
Park, H.-C., Kim, C.-H., Bae, Y.-K., Yee, S.-Y., Kim, S.-H., Hong, S.-K., Shin, J., Yoo, K.-W., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T.-L. (2000) Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. Developmental Biology. 227(2):279-293
Park, H.-C., Hong, S.-K., Kim, H.-S., Kim, S.-H., Yoon, E.-J., Kim, C.-H., Miki, N., and Huh, T.-L. (2000) Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. Neuroscience letters. 279(2):81-84
Kim, S.-H., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Choi, J.W., Kim, C.-H., Weinstein, B.M., and Huh, T.-L. (1998) Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos. Mechanisms of Development. 78:193-201