ZFIN ID: ZDB-LAB-130513-1
Fangyuan Chen Lab
PI/Director: Chen, Fangyuan
Contact Person: Chen, Fangyuan
Email: chenfangyuan62@163.com
Address: No.1630, Dongfang Road, Shanghai200127, China
Country: China
Phone: +86(21)68383301
Fax: +86(21)58395057
Line Designation: rji

Show all 2 genomic features

In recent years, study on the transcriptional networks by which the proto-oncogenes and angiogenesis play their roles in human AML, involved in pathogenesis, infiltration and prognosis assessment, has become the focus of targeted therapy and comprehensive therapy. Zebrafish has become a powerful model organism for studying the gene function. The main aim of our work is to study the biological characteristics of zebrafish organism and its potential model for human blood developmental biology and hematologic malignancies.

Shen, Li-Jing Post-Doc Zhang, Yong Post-Doc Liu, Hai-yan Graduate Student
Zhou, Li-Yun Graduate Student Zhong, Ji-Hua Technical Staff

Lang, W., Han, X., Cai, J., Chen, F., Xu, L., Zhong, H., Zhong, J. (2022) Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia. Cellular Signalling. 99:110402
Xiao, L., Guo, Y., Wang, D., Zhao, M., Hou, X., Li, S., Lin, H., Zhang, Y. (2020) Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Frontiers in genetics. 11:161
Lang, W., Cai, J., Chen, F., Zhu, J., Hu, X., Zhong, J. (2019) RNA-Seq Analyses Demonstrate EVI-1-induced Morbid Hematopoiesis and Developmental Abnormality in Zebrafish were Related with MAPK Pathway. Hematological oncology.
Lang, W., Zhu, J., Chen, F., Cai, J., Zhong, J. (2018) EVI-1 Modulates Arsenic Trioxide induced Apoptosis through JNK signaling pathway in Leukemia Cells. Experimental cell research. 374(1):140-151
Chen, Y., Zeng, S., Hu, R., Wang, X., Huang, W., Liu, J., Wang, L., Liu, G., Cao, Y., Zhang, Y. (2017) Using local chromatin structure to improve CRISPR/Cas9 efficiency in zebrafish. PLoS One. 12:e0182528
Liu, H., Fu, B., Pang, M., Feng, X., Yu, X., Tong, J. (2017) A High-Density Genetic Linkage Map and QTL Fine Mapping for Body Weight in Crucian Carp (Carassius auratus) Using 2b-RAD Sequencing.. G3 (Bethesda). 7(8):2473-2487
Liu, Y., Zhu, Z., Ho, I.H., Shi, Y., Xie, Y., Li, J., Zhang, Y., Chan, M.T., Cheng, C.H. (2017) Germline-specific dgcr8 knockout in zebrafish using a BACK approach. Cellular and molecular life sciences : CMLS. 74(13):2503–2511
Chen, X., Dong, Q., Chen, Y., Zhang, Z., Huang, C., Zhu, Y., Zhang, Y. (2017) Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish. Environmental pollution (Barking, Essex : 1987). 224:7-15
Simon, A.J., Lev, A., Zhang, Y., Weiss, B., Rylova, A., Eyal, E., Kol, N., Barel, O., Cesarkas, K., Soudack, M., Greenberg-Kushnir, N., Rhodes, M., Wiest, D.L., Schiby, G., Barshack, I., Katz, S., Pras, E., Poran, H., Reznik-Wolf, H., Ribakovsky, E., Simon, C., Hazou, W., Sidi, Y., Lahad, A., Katzir, H., Sagie, S., Aqeilan, H.A., Glousker, G., Amariglio, N., Tzfati, Y., Selig, S., Rechavi, G., Somech, R. (2016) Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. The Journal of experimental medicine. 213(8):1429-40
Tang, H., Liu, Y., Li, J., Yin, Y., Li, G., Chen, Y., Li, S., Zhang, Y., Lin, H., Liu, X., Cheng, C.H. (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Scientific Reports. 6:28545
Zhong, Z., Yang, L., Zhang, Y.E., Xue, Y., He, S. (2016) Correlated expression of retrocopies and parental genes in zebrafish. Molecular genetics and genomics : MGG. 291(2):723-37
Zhang, Y., Wiest, D.L. (2016) Using the Zebrafish Model to Study T Cell Development. Methods in molecular biology (Clifton, N.J.). 1323:273-92
Shen, L., Zhu, J., Chen, F., Lin, W., Cai, J., Zhong, J., Zhong, H. (2015) RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC cancer. 15:970
Seiler, C., Gebhart, N., Zhang, Y., Shinton, S.A., Li, Y.S., Ross, N.L., Liu, X., Li, Q., Bilbee, A.N., Varshney, G.K., LaFave, M.C., Burgess, S.M., Balciuniene, J., Balciunas, D., Hardy, R.R., Kappes, D.J., Wiest, D.L., Rhodes, J. (2015) Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PLoS One. 10:e0131908
Wang, Y., Lu, Y., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X., Feng, Q., Liang, X., Liu, K., Zhang, L., Lu, T., Huang, T., Fan, D., Weng, Q., Zhu, C., Lu, Y., Li, W., Wen, Z., Zhou, C., Tian, Q., Kang, X., Shi, M., Zhang, W., Jang, S., Du, F., He, S., Liao, L., Li, Y., Gui, B., He, H., Ning, Z., Yang, C., He, L., Luo, L., Yang, R., Luo, Q., Liu, X., Li, S., Huang, W., Xiao, L., Lin, H., Han, B., Zhu, Z. (2015) The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature Genetics. 47(6):625-31
Brown, A.R., Owen, S.F., Peters, J., Zhang, Y., Soffker, M., Paull, G.C., Hosken, D.J., Wahab, M.A., Tyler, C.R. (2015) Climate change and pollution speed declines in zebrafish populations. Proceedings of the National Academy of Sciences of the United States of America. 112(11):E1237-46
Yang, R., Lao, Q.C., Yu, H.P., Zhang, Y., Liu, H.C., Luan, L., Sun, H.M., Li, C.Q. (2015) Tween-80 and impurity induce anaphylactoid reaction in zebrafish. Journal of applied toxicology : JAT. 35(3):295-301
Tang, H., Liu, Y., Luo, D., Ogawa, S., Yin, Y., Li, S., Zhang, Y., Hu, W., Parhar, I.S., Lin, H., Liu, X., Cheng, C.H. (2015) The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology. 156(2):589-99
Zhang, Y., Vastenhouw, N.L., Feng, J., Fu, K., Wang, C., Ge, Y., Pauli, A., van Hummelen, P., Schier, A.F., and Liu, X.S. (2014) Canonical nucleosome organization at promoters forms during genome activation. Genome research. 24(2):260-6
Liu, Y., Li, S., Qi, X., Zhou, W., Liu, X., Lin, H., Zhang, Y., and Cheng, C.H. (2013) A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus. Molecular and Cellular Endocrinology. 374(1-2):65-72
Liu, Y., Li, S., Huang, X., Lu, D., Liu, X., Ko, W.H., Zhang, Y., Cheng, C.H., and Lin, H. (2013) Identification and characterization of a motilin-like peptide and its receptor in teleost. General and comparative endocrinology. 186:85-93
Shen, L.J., Cao, L.F., Chen, F.Y., Zhang, Y., Zhong, J.H., and Zhong, H. (2013) Using modified whole-mount in situ hybridization to study mpo expression in zebrafish.. Experimental and Therapeutic Medicine. 5(4):1043-1047
Shen, L.J., Chen, F.Y., Zhang, Y., Cao, L.F., Kuang, Y., Zhong, M., Wang, T., and Zhong, H. (2013) MYCN Transgenic Zebrafish Model with the Characterization of Acute Myeloid Leukemia and Altered Hematopoiesis. PLoS One. 8(3):e59070
Zhou, W., Li, S., Liu, Y., Qi, X., Chen, H., Cheng, C.H., Liu, X., Zhang, Y., and Lin, H. (2012) The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio). Molecular and Cellular Endocrinology. 361(1-2):202-212
Zhuo, Q., Zhang, Y., Huang, W., Liu, X., Li, Y., Zhu, P., Lu, D., and Lin, H. (2011) Cloning, characterization, sequence analysis and expression patterns in vivo of testicular 20β-hydroxysteroid dehydrogenase cDNA in yellow catfish (Pelteobagrus fulvidraco). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 159(3):171-182
Yuan, H., Zhou, J., Deng, M., Zhang, Y., Chen, Y., Jin, Y., Zhu, J., Chen, S.J., The, H.D., Chen, Z., Liu, T.X., and Zhu, J. (2011) Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish. Blood. 117(26):7014-7020
Liu, Y., Lu, D., Zhang, Y., Li, S., Liu, X., and Lin, H. (2010) The evolution of somatostatin in vertebrates. Gene. 463(1-2):21-28
Zhang, Y., Li, S., Liu, Y., Lu, D., Chen, H., Huang, X., Liu, X., Meng, Z., Lin, H., and Cheng, C.H. (2010) Structural diversity of the gnih/gnih receptor system in teleost: its involvement in early development and the negative control of LH release. Peptides. 31(6):1034-1043
Zhang, Y., Chen, F.Y., and Deng, M. (2009) Research progress of zebrafish as a model system for hematological neoplasms. Yi chuan = Hereditas. 31(9):889-895
Liu, X., Zhu, P., Sham, K.W., Yuen, J.M., Xie, C., Zhang, Y., Liu, Y., Li, S., Huang, X., Cheng, C.H., and Lin, H. (2009) Identification of a Membrane Estrogen Receptor in Zebrafish with Homology to Mammalian GPER and Its High Expression in Early Germ Cells of the Testis. Biology of reproduction. 80(6):1253-1261
Zhang, Y., Liu, Y., Huang, X., Liu, X., Jiao, B., Meng, Z., Zhu, P., Li, S., Lin, H., and Cheng, C. (2008) Two alternatively spliced GPR39 transcripts in seabream: molecular cloning, genomic organization and regulation of gene expression by metabolic signals. The Journal of endocrinology. 199(3):457-470
Wang, L., Zhang, Y., Zhou, T., Fu, Y.F., Du, T.T., Jin, Y., Chen, Y., Ren, C.G., Peng, X.L., Deng, M., and Liu, T.X. (2008) Functional characterization of lmo2-Cre transgenic zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(8):2139-2146
Le, H.Y., Zhang, Y., Liu, H., Ma, L.H., Jin, Y., Huang, Q.H., Chen, Y., Deng, M., Chen, Z., Chen, S.J., and Liu, T. (2008) EENA promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. The Journal of biological chemistry. 283(25):17652-17661
Sun, X.J., Xu, P.F., Zhou, T., Hu, M., Fu, C.T., Zhang, Y., Jin, Y., Chen, Y., Chen, S.J., Huang, Q.H., Liu, T.X., and Chen, Z. (2008) Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS One. 3(1):e1499
Huang, X., Jiao, B., Fung, C.K., Zhang, Y., Ho, W.K., Chan, C.B., Lin, H., Wang, D., and Cheng, C.H. (2007) The presence of two distinct prolactin receptors in seabream with different tissue distribution patterns, signal transduction pathways and regulation of gene expression by steroid hormones. The Journal of endocrinology. 194(2):373-392