ZFIN Lab: Raya Lab

ZFIN ID: ZDB-LAB-130114-1

Raya Lab

PI/Director:	Raya, Angel
Contact Person:	Raya, Angel
Email:	araya@idibell.cat
URL:	https://p-cmrc.cat/research/raya-group/
Address:	Regenerative Medicine Program Bellvitge Biomedical Research Institute (IDIBELL) Hospital Duran i Reynals, 3rd floor Av. Gran Via 199-203 08908 Hospitalet de Llobregat (Barcelona) Spain
Country:	Spain
Phone:	+34 93 607 3821
Fax:
Line Designation:	cmr

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

Our laboratory employs a multipronged approach to address one basic question: How can a discrete and defined degree of developmental potency be imposed onto a somatic cell so that it regains the ability to regenerate a functional tissue or structure? For this purpose, we use in vivo approaches in animal models (zebrafish heart regeneration), as well as cell-based paradigms built around human pluripotent stem cells.

LAB MEMBERS

Castillo-Robles, Jorge Post-Doc

Garcia-Pastor, Cristina Technical Staff

Jimenez-Delgado, Senda Technical Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Garcia-Puig, A., Mosquera, J.L., Jiménez-Delgado, S., García-Pastor, C., Jorba, I., Navajas, D., Canals, F., Raya, A. (2019) Proteomics analysis of extracellular matrix remodeling during zebrafish heart regeneration. Molecular & cellular proteomics : MCP. 18(9):1745-1755

Uroz, M., Garcia-Puig, A., Tekeli, I., Elosegui-Artola, A., Abenza, J.F., Marín-Llauradó, A., Pujals, S., Conte, V., Albertazzi, L., Roca-Cusachs, P., Raya, Á., Trepat, X. (2019) Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium. Nature Materials. 18(9):1015-1023

Tekeli, I., Garcia-Puig, A., Notari, M., García-Pastor, C., Aujard, I., Jullien, L., Raya, A. (2017) Fate predetermination of cardiac myocytes during zebrafish heart regeneration. Open Biology. 7(6)

Bedford-Guaus, S.J., Chauvigné, F., Mejía-Ramírez, E., Martí, M., Ventura-Rubio, A., Raya, Á., Cerdà, J., Veiga, A. (2016) Expression of the T85A mutant of zebrafish aquaporin 3b improves post-thaw survival of cryopreserved early mammalian embryos. Zygote (Cambridge, England). 24(6):839-847

Tekeli, I., Aujard, I., Trepat, X., Jullien, L., Raya, A., Zalvidea, D. (2016) Long-term in vivo single-cell lineage tracing of deep structures using three-photon activation.. Light, science & applications. 5:e16084

Sleep, E., Boué, S., Jopling, C., Raya, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Transcriptomics approach to investigate zebrafish heart regeneration. Journal of cardiovascular medicine (Hagerstown, Md.). 11(5):369-380

Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 464(7288):606-609

Raya, A., and Izpisúa Belmonte, J.C. (2008) Insights into the establishment of left-right asymmetries in vertebrates. Birth defects research. Part C, Embryo today : reviews. 84(2):81-94

Ribeiro, I., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., and Izpisua Belmonte, J.C. (2007) Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling. PLoS One. 2(1):e398

Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2007) miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. Nature clinical practice. Cardiovascular medicine. 4(1):S77-S82

Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., and Izpisúa Belmonte, J.C. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nature Genetics. 38(11):1316-1322

Raya, A., and Izpisúa Belmonte, J.C. (2006) Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nature reviews. Genetics. 7(4):283-293

Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2005) Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 435(7039):165-171

Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes & Development. 19(1):164-175

Raya, A., and Izpisúa Belmonte, J.C. (2004) Sequential transfer of left-right information during vertebrate embryo development. Current opinion in genetics & development. 14(5):575-581

Huang, Q., Raya, A., DeJesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisúa Belmonte, J.C., and Schultz, P.G. (2004) Identification of p53 regulators by genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 101(10):3456-3461

Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2004) The zebrafish as a model of heart regeneration. Cloning and stem cells. 6(4):345-351

Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa Belmonte, J.C., and De La Pompa, J.L. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development. 18(1):99-115

Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternick, G., Tsai, H.J., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2003) Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. (Suppl. 1) 100:11889-11895

Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez-Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H., and Izpisúa Belmonte, J.C. (2003) MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature cell biology. 5(6):513-519

Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M., Raya, R.M., Dubova, I., Bessa, J.G., de la Pompa, J.L., and Izpisúa Belmonte, J.C. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes & Development. 17(10):1213-1218

Ng, J.K., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C.M., Rodriguez-Esteban, C., Rodríguez-León, J., Garrity, D.M., Fishman, M.C., and Izpisúa Belmonte, J.C. (2002) The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development (Cambridge, England). 129(22):5161-5170