ZFIN Lab: The Center for Heart Development

ZFIN ID: ZDB-LAB-110609-1

ZFIN ID: ZDB-LAB-110609-1

The Center for Heart Development

PI/Director:	Wu, Xiushan
Contact Person:	Wu, Xiushan
Email:	xiushanwu@yahoo.com
URL:	http://lifescience.hunnu.edu.cn/teacher/t/572.html
Address:	College of Life Science Hunan Normal University Changsha, 410081, Hunan P. R. China
Country:	China
Phone:	+86-0731-88872780
Fax:	+86-0731-88615078
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

The focus of our current research is to identify novel genes involved in heart development and to clarify the molecular mechanisms that lead to normal cardiac morphogenesis and function in vivo by generating transgenic and knockout zebrafish.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):

Liu, H., Chen, Y., Hu, W., Luo, Y., Zhu, P., You, S., Li, Y., Jiang, Z., Wu, X., Li, X. (2022) Impacts of PFOA_C8, GenX_C6, and their mixtures on zebrafish developmental toxicity and gene expression provide insight about tumor-related disease. The Science of the total environment. 858(Pt 2):160085

Luo, K., Zheng, C., Luo, R., Cao, X., Sun, H., Ma, H., Huang, J., Yang, X., Wu, X., Li, X. (2022) Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy. BMC Medical Genomics. 15:189

Chen, F., Yuan, W., Mo, X., Zhuang, J., Wang, Y., Chen, J., Jiang, Z., Zhu, X., Zeng, Q., Wan, Y., Li, F., Shi, Y., Cao, L., Fan, X., Luo, S., Ye, X., Chen, Y., Dai, G., Gao, J., Wang, X., Xie, H., Zhu, P., Li, Y., Wu, X. (2018) Role of zebrafish fhl1A in satellite cell and skeletal muscle development. Current Molecular Medicine. 17(9):627-636

Zhou, Z., Peng, X., Chen, J., Wu, X., Wang, Y., Hong, Y. (2016) Identification of zebrafish magnetoreceptor and cryptochrome homologs. Science China. Life sciences. 59(12):1324-1331

Peng, X., Li, G., Wang, Y., Zhuang, J., Luo, R., Chen, J., Chen, F., Shi, Y., Li, J., Zhou, Z., Mo, X., Liu, X., Yuan, W., Zeng, Q., Li, Y., Jiang, Z., Wan, Y., Ye, X., Xu, W., Wang, X., Fan, X., Zhu, P., Wu, X., Deng, Y. (2016) CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish. International Journal of Cardiology. 214:246-253

Xie, H., Fan, X., Tang, X., Wan, Y., Chen, F., Wang, X., Wang, Y., Li, Y., Tang, M., Liu, D., Jiang, Z., Liu, X., Yuan, W., Li, G., Ye, X., Zhou, J., Deng, Y., and Wu, X. (2013) The LIM protein fhlA is essential for heart chamber development in zebrafish embryos. Current Molecular Medicine. 13(6):979-92

Peng, X.Y., Chen, T.F., Huang, T., Jiang, Z.G., Wu, X.S., and Deng, Y. (2013) Construction and assessment of heart-specific green fluorescence zebrafish line. Yi chuan = Hereditas. 35(4):511-518

Huang, W., Deng, Y., Dong, W., Yuan, W., Wan, Y., Mo, X., Li, Y., Wang, Z., Wang, Y., Ocorr, K., Zhang, B., Lin, S., and Wu, X. (2011) The effect of excess expression of GFP in a novel heart-specific green fluorescence zebrafish regulated by nppa enhancer at early embryonic development. Molecular biology reports. 38(2):793-799

Chen, T., Luo, N., Xie, H., Wu, X., and Deng, Y. (2010) Construction and expression analysis of the zebrafish heart-specific transgenetic vector based on Tol2 transposable element. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 26(2):230-236