ZFIN Lab: Holzschuh Lab

ZFIN ID: ZDB-LAB-070628-1

ZFIN ID: ZDB-LAB-070628-1

Holzschuh Lab

PI/Director:	Holzschuh, Jochen
Contact Person:	Holzschuh, Jochen
Email:	jochen.holzschuh@biologie.uni-freiburg.de
URL:	http://www.biologie.uni-freiburg.de/data/bio1/holzschuh/
Address:	University of Freiburg Biology I, Dept. Developmental Biology Hauptstraße 1 79104 Freiburg Germany
Country:	Germany
Phone:	Office: ++49 761-203-2516 Lab: ++49 761-203-2537
Fax:	++49 761-203-2597
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our laboratory aims to understand how signaling molecules and neuron specific transcription factors cooperate to regulate the differentiation of noradrenergic neurons in the brainstem and regulate the development of the respiratory network in zebrafish. With our research we hope to gain a better understanding of respiratory disorders in humans.

Our lab is also interested in the molecular and cellular mechanisms, which regulate the differentiation of neural crest cells to neurons of the peripheric nervous system, the sympathetic ganglia and enteric ganglia.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Hu, Z., Holzschuh, J., Driever, W. (2015) Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos. PLoS One. 10:e0134299

Reichenbach, B., Delalande, J.M., Kolmogorova, E., Prier, A., Nguyen, T., Smith, C.M., Holzschuh, J., and Shepherd, I.T. (2008) Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Developmental Biology. 318(1):52-64

Filippi, A., Duerr, K., Ryu, S., Willaredt, M., Holzschuh, J., and Driever, W. (2007) Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development. BMC Developmental Biology. 7(1):135

Ryu, S., Mahler, J., Acampora, D., Holzschuh, J., Erhardt, S., Omodei, D., Simeone, A., and Driever, W. (2007) Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development. Current biology : CB. 17(10):873-880

Isken, A., Holzschuh, J., Lampert, J.M., Fischer, L., Oberhauser, V., Palczewski, K., and von Lintig, J. (2007) Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. The Journal of biological chemistry. 282(2):1144-1151

Ettl, A.K., Holzschuh, J., and Driever, W. (2006) The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus. Anatomy and embryology. 211(7):73-86

Durr, K., Holzschuh, J., Filippi, A., Ettl, A.K., Ryu, S., Shepherd, I.T., and Driever, W. (2006) Differential Roles of Transcriptional Mediator Complex Subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 During Zebrafish Retinal Development. Genetics. 174(2):693-705

Ryu, S., Holzschuh, J., Mahler, J., and Driever, W. (2006) Genetic analysis of dopaminergic system development in zebrafish. Journal of neural transmission. Supplementum. 70:61-66

Ryu, S., Holzschuh, J., Erhardt, S., Ettl, A.K., and Driever, W. (2005) Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18467-18472

Holzschuh, J., Wada, N., Wada, C., Schaffer, A., Javidan, Y., Tallafuss, A., Bally-Cuif, L., and Schilling, T.F. (2005) Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development (Cambridge, England). 132(16):3731-3742

Barrallo Gimeno, A., Holzschuh, J., Driever, W., and Knapik, E.W. (2004) Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Development (Cambridge, England). 131(7):1463-1477

Holzschuh, J., Barrallo Gimeno, A., Ettl, A.K., Durr, K., Knapik, E.W., and Driever, W. (2003) Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Development (Cambridge, England). 130(23):5741-5754

Holzschuh, J., Hauptmann, G., and Driever, W. (2003) Genetic analysis of the roles of Hh, FGF8, and nodal signaling during catecholaminergic system development in the zebrafish brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(13):5507-5519

Lampert, J.M., Holzschuh, J., Hessel, S., Driever, W., Vogt, K., and von Lintig, J. (2003) Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis. Development (Cambridge, England). 130(10):2173-2186

Biemar, F., Baraldi, F., Devos, N., Holzschuh, J., Martial, J.A., Driever, W., and Peers, B. (2002) Analysis of meis genes expression in zebrafish suggests a role in the development of organs derived from the endoderm. Developmental Biology. 247(2):495

Holzschuh, J., Ryu, S., Aberger, F., and Driever, W. (2001) Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of Development. 101(1-2):237-243