ZFIN ID: ZDB-LAB-041207-2
Levenson Lab
PI/Director: Levenson, Robert
Co-PI / Senior
Researcher:		 Canfield, Victor
Contact Person: Petko, Jessica
Email: jac554@psu.edu
URL: http://fred.hmc.psu.edu/faculty/rlevenson
Address: Department of Pharmacology Penn State University College of Medicine Milton S. Hershey Medical Center 500 University Drive Hershey, PA 17033 USA
Country: United States
Phone: (717) 531-4545
Fax: (717) 531-5013
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Our lab is located in the Pharmacology Department at the Penn State College of Medicine. Our research interests involving zebrafish as the model system lie within two areas.

1. Cloning and characterizing known and novel members of the dopamine signaling pathway.


2. Identifying and characterizing genes involved in inner ear development.

3. Identifying novel members of the Mu-opiod receptor signaling pathway that may be involved in drug addiction.


LAB MEMBERS
Petko, Jessica Graduate Student Woll, Matt Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Katz, S.R., Yakovlev, M.A., Vanselow, D.J., Ding, Y., Lin, A.Y., Parkinson, D.Y., Wang, Y., Canfield, V.A., Ang, K.C., Cheng, K.C. (2021) Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT. eLIFE. 10:
Ding, Y., Vanselow, D.J., Yakovlev, M.A., Katz, S.R., Lin, A.Y., Clark, D.P., Vargas, P., Xin, X., Copper, J.E., Canfield, V.A., Ang, K.C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D.B., La Riviere, P., Cheng, K. (2019) Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography. eLIFE. 8:
Boehmler, W., Petko, J., Canfield, V.A., and Levenson, R. (2013) Genomic strategies for the identification of dopamine receptor genes in zebrafish. Methods in molecular biology (Clifton, N.J.). 964:201-214
Tsetskhladze, Z.R., Canfield, V.A., Ang, K.C., Wentzel, S.M., Reid, K.P., Berg, A.S., Johnson, S.L., Kawakami, K., and Cheng, K.C. (2012) Functional assessment of human coding mutations affecting skin pigmentation using zebrafish. PLoS One. 7(10):e47398
Jin, J., Morse, M., Frey, C., Petko, J., and Levenson, R. (2010) Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(9):2426-2434
Petko, J.A., Kabbani, N., Frey, C., Woll, M., Hickey, K., Craig, M., Canfield, V.A., and Levenson, R. (2009) Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neuroscience. 10:27
Boehmler, W., Petko, J., Woll, M., Frey, C., Thisse, B., Thisse, C., Canfield, V.A., and Levenson, R. (2009) Identification of zebrafish A2 adenosine receptors and expression in developing embryos. Gene expression patterns : GEP. 9(3):144-151
Petko, J.A., Millimaki, B.B., Canfield, V.A., Riley, B.B., and Levenson, R. (2008) Otoc1: A novel otoconin-90 ortholog required for otolith mineralization in zebrafish. Developmental Neurobiology. 68(2):209-222
Boehmler, W., Carr, T., Thisse, C., Thisse, B., Canfield, V.A., and Levenson, R. (2007) D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes, brain, and behavior. 6(2):155-166
Blasiole, B., Canfield, V.A., Vollrath, M.A., Huss, D., Mohideen, M.A., Dickman, J.D., Cheng, K.C., Fekete, D.M., and Levenson, R. (2006) Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish. Developmental Biology. 294(1):148-160
Lamason, R.L., Mohideen, M.A., Mest, J.R., Wong, A.C., Norton, H.L., Aros, M.C., Jurynec, M.J., Mao, X., Humphreville, V.R., Humbert, J.E., Sinha, S., Moore, J.L., Jagadeeswaran, P., Zhao, W., Ning, G., Makalowska, I., McKeigue, P.M., O'donnell, D., Kittles, R., Parra, E.J., Mangini, N.J., Grunwald, D.J., Shriver, M.D., Canfield, V.A., and Cheng, K.C. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (New York, N.Y.). 310(5755):1782-1786
Croushore, J.A., Blasiole, B., Riddle, R.C., Thisse, C., Thisse, B., Canfield, V.A., Robertson, G.P., Cheng, K.C., and Levenson, R. (2005) Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(4):911-921
Blasiole, B., Kabbani, N., Boehmler, W., Thisse, B., Thisse, C., Canfield, V., and Levenson, R. (2005) Neuronal calcium sensor-1 gene ncs-1a is essential for semicircular canal formation in zebrafish inner ear. Journal of neurobiology. 64(3):285-297
Hughes, I., Blasiole, B., Huss, D., Warchol, M.E., Rath, N.P., Hurle, B., Ignatova, E., David Dickman, J., Thalmann, R., Levenson, R., and Ornitz, D.M. (2004) Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Developmental Biology. 276(2):391-402
Boehmler, W., Obrecht-Pflumio, S., Canfield, V., Thisse, C., Thisse, B., and Levenson, R. (2004) Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(3):481-493
Blasiole, B., Degrave, A., Canfield, V., Boehmier, W., Thisse, C., Thisse, B., Mohideen, M.A., and Levenson, R. (2003) Differential expression of Na,K-ATPase alpha and beta subunit genes in the developing zebrafish inner ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):386-392
Cheng, K.C., Levenson, R., and Robishaw, J.D. (2003) Functional genomic dissection of multimeric protein families in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):555-567
Blasiole, B., Canfield, V., Degrave, A., Thisse, C., Thisse, B., Rajarao, J., and Levenson, R. (2002) RETRACTED: Cloning, mapping, and developmental expression of a sixth zebrafish Na,K-ATPase alpha1 subunit gene (atp1a1a.5). Gene expression patterns : GEP. 2(3-4):243-246
Blasiole, B., Canfield, V., Degrave, A., Thisse, C., Thisse, B., Rajarao, J., and Levenson, R. (2002) Cloning, mapping, and developmental expression of a sixth zebrafish Na,K-ATPase alpha1 subunit gene (atp1a1a.5). Mechanisms of Development. (Suppl.) 119:S211-S214
Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Postlethwait, J.H., Mohideen, A.P.K., Rajarao, S.J.R., and Levenson, R. (2002) Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis. Mechanisms of Development. 116(1-2):51-59
Rajarao, J.R., Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Yan, Y.-L., Postlethwait, J.H., and Levenson, R. (2002) Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(2):254-261
Rajarao, S.J., Canfield, V.A., Mohideen, M.A., Yan, Y.-L., Postlethwait, J.H., Cheng, K.C., and Levenson, R. (2001) The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Genome research. 11(7):1211-1220
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