ZFIN ID: ZDB-LAB-030703-1
Artinger Lab
PI/Director: Artinger, Kristin Bruk
Contact Person: Artinger, Kristin Bruk
Email: kristin.artinger@ucdenver.edu
URL: http://artingerlab.org
Address: Department of Craniofacial Biology University of Colorado Denver School of Dental Medicine 12801 East 17th Ave. Mail Stop 8120 P.O. Box 6511 Aurora, CO 80045 USA
Country: United States
Phone: (303) 724-4562
Fax: (303) 724-4580
Line Designation: co


GENOMIC FEATURES ORIGINATING FROM THIS LABNo data available


STATEMENT OF RESEARCH INTERESTS
Research in my lab is directed toward an understanding of the molecular, genetic and developmental mechanisms involved in neural crest cell development. Neural crest cells, have the extraordinary ability to retain stem cell-like characteristics during development and give rise to multiple derivatives, including peripheral neurons, pigment cells and craniofacial cartilage, which form most of the vertebrate face. We focus on transcriptional regulation of neural crest specification, differentiation into craniofacial structures, and formation of sensory cells in the peripheral nervous system.


LAB MEMBERS
Anderson, Keith Post-Doc Ding, Hailei Post-Doc Johnson, Christopher Graduate Student
Law, Jera Graduate Student Powell, Davalyn Graduate Student Hernandez, Laura Research Staff
Singleton, Morgan Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Iklé, J.M., Tavares, A.L., King, M., Ding, H., Colombo, S., Firulli, B.A., Fiulli, A.B., Targoff, K.L., Yelon, D., Clouthier, D.E. (2017) Nkx2.5 regulates Endothelin Converting Enzyme-1 during pharyngeal arch patterning. Genesis (New York, N.Y. : 2000). 55(3)
Van Otterloo, E., Williams, T., Artinger, K.B. (2016) The Old And New Face Of Craniofacial Research: How Animal Models Inform Human Craniofacial Genetic And Clinical Data. Developmental Biology. 415(2):171-87
Ding, H.L., Hooper, J.E., Batzel, P., Eames, B.F., Postlethwait, J.H., Artinger, K.B., Clouthier, D.E. (2016) MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b. Frontiers in Physiology. 7:281
Powell, D.R., Williams, J.S., Hernandez-Lagunas, L., Salcedo, E., O'Brien, J.H., Bruk Artinger, K. (2015) Cdon promotes neural crest migration by regulating N-cadherin localization. Developmental Biology. 407(2):289-99
LaMonica, K., Ding, H.L., Artinger, K.B. (2015) prdm1a functions upstream of itga5 in zebrafish craniofacial development. Genesis (New York, N.Y. : 2000). 53(3-4):270-7
Tavares, A.L., Artinger, K.B., Clouthier, D.E. (2015) Regulating Craniofacial Development at the 3' End: MicroRNAs and Their Function in Facial Morphogenesis. Current topics in developmental biology. 115:335-75
Quintana, A.M., Geiger, E.A., Achilly, N., Rosenblatt, D.S., Maclean, K.N., Stabler, S.P., Artinger, K.B., Appel, B., Shaikh, T.H. (2014) Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating MMACHC expression. Developmental Biology. 396(1):94-106
O'Brien, J.H., Hernandez-Lagunas, L., Artinger, K.B., Ford, H.L. (2014) MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1. Journal of Cell Science. 127(Pt 10):2291-301
Cottee, M.A., Muschalik, N., Wong, Y.L., Johnson, C.M., Johnson, S., Andreeva, A., Oegema, K., Lea, S.M., Raff, J.W., and van Breugel, M. (2013) Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly. eLIFE. 2:e01071
Powell, D.R., Hernandez-Lagunas, L., Lamonica, K., and Artinger, K.B. (2013) Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification. Development (Cambridge, England). 140(16):3445-3455
Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
Howe, K., Clark, M.D., Torroja, C.F., Torrance, J., Berthelot, C., Muffato, M., Collins, J.E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J.C., Koch, R., Rauch, G.J., White, S., Chow, W., Kilian, B., Quintais, L.T., Guerra-Assunção, J.A., Zhou, Y., Gu, Y., Yen, J., Vogel, J.H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S.F., Laird, G.K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Eliott, D., Threadgold, G., Harden, G., Ware, D., Mortimer, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C.M., Ersan-Ürün, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberländer, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., Rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N.P., Harrow, J., Ning, Z., Herrero, J., Searle, S.M., Enright, A., Geisler, R., Plasterk, R.H., Lee, C., Westerfield, M., de Jong, P.J., Zon, L.I., Postlethwait, J.H., Nüsslein-Volhard, C., Hubbard, T.J., Crollius, H.R., Rogers, J., and Stemple, D.L. (2013) The zebrafish reference genome sequence and its relationship to the human genome. Nature. 496:498-503
Ding, H.L., Clouthier, D.E., and Artinger, K.B. (2013) Redundant roles of PRDM family members in zebrafish craniofacial development. Developmental dynamics : an official publication of the American Association of Anatomists. 242(1):67-79
Iklé, J.M., Artinger, K.B., and Clouthier, D.E. (2012) Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2. Developmental Biology. 368(1):118-126
Johnson, C.W., Hernandez-Lagunas, L., Feng, W., Melvin, V.S., Williams, T., and Artinger, K.B. (2011) Vgll2a is required for neural crest cell survival during zebrafish craniofacial development. Developmental Biology. 357(1):269-81
Anderson, K.R., Singer, R.A., Balderes, D.A., Hernandez-Lagunas, L., Johnson, C.W., Artinger, K.B., and Sussel, L. (2011) The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development (Cambridge, England). 138(15):3213-3224
Hochheiser, H., Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Hallgrimsson, B., Iwata, J., Klein, O., Marazita, M.L., Murray, J.C., Murray, S., de Villena, F.P., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M., and Trainor, P.A. (2011) The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Developmental Biology. 355(2):175-182
van Breugel, M., Hirono, M., Andreeva, A., Yanagisawa, H.A., Yamaguchi, S., Nakazawa, Y., Morgner, N., Petrovich, M., Ebong, I.O., Robinson, C.V., Johnson, C.M., Veprintsev, D., and Zuber, B. (2011) Structures of SAS-6 Suggest Its Organization in Centrioles. Science (New York, N.Y.). 331(6021):1196-1199
Olesnicky, E., Hernandez-Lagunas, L., and Artinger, K.B. (2010) Prdm1a regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. Genesis (New York, N.Y. : 2000). 48(11):656-666
Klymkowsky, M.W., Rossi, C.C., and Artinger, K.B. (2010) Mechanisms driving neural crest induction and migration in the zebrafish and Xenopus laevis. Cell adhesion & migration. 4(4):595-608
Birkholz, D.A., Killian, E.C., George, K.M., and Artinger, K.B. (2009) Prdm1a is necessary for posterior pharyngeal arch development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(10):2575-2587
Olesnicky Killian, E.C., Birkholz, D.A., and Artinger, K.B. (2009) A role for chemokine signaling in neural crest cell migration and craniofacial development. Developmental Biology. 333(1):161-172
Rossi, C.C., Kaji, T., and Artinger, K.B. (2009) Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border. Developmental dynamics : an official publication of the American Association of Anatomists. 238(4):931-943
Wenzlau, J.M., Garl, P.J., Simpson, P., Stenmark, K.R., West, J., Artinger, K.B., Nemenoff, R.A., and Weiser-Evans, M.C. (2006) Embryonic Growth-Associated Protein Is One Subunit of a Novel N-Terminal Acetyltransferase Complex Essential for Embryonic Vascular Development. Circulation research. 98(6):846-855
Hernandez-Lagunas, L., Choi, I.F., Kaji, T., Simpson, P., Hershey, C., Zhou, Y., Zon, L., Mercola, M., and Artinger, K.B. (2005) Zebrafish narrowminded disrupts the transcription factor prdm1 and is required for neural crest and sensory neuron specification. Developmental Biology. 278(2):347-357
Kaji, T., and Artinger, K.B. (2004) dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula. Developmental Biology. 276(2):523-540
Zhang, C., Basta, T., Hernandez-Lagunas, L., Simpson, P., Stemple, D.L., Artinger, K.B., and Klymkowsky, M.W. (2004) Repression of nodal expression by maternal B1-type SOXs regulates germ layer formation in Xenopus and zebrafish. Developmental Biology. 273(1):23-37
Belting, H.G., Hauptmann, G., Meyer, D., Abdelilah-Seyfried, S., Chitnis, A., Eschbach, C., Söll, I., Thisse, C., Thisse, B., Artinger, K., Lunde, K., and Driever, W. (2001) spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer. Development (Cambridge, England). 128(21):4165-4176
Kim, C.H., Oda, T., Itoh, M., Jiang, D., Artinger, K.B., Chandrasekharappa, S.C., Driever, W., and Chitnis, A.B. (2000) Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature. 407(6806):913-916
Artinger, K.B., Chitnis, A.B., Mercola, M., and Driever, W. (1999) Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons. Development (Cambridge, England). 126(18):3969-3979