ZFIN ID: ZDB-LAB-010309-1
Plasterk Lab
PI/Director: Plasterk, Ronald H.A.
Contact Person: Plasterk, Ronald H.A.
Email:
URL:
Address: Hubrecht Laboratory Netherlands Institute for Developmental Biology Uppsalalaan 8 3584CT Utrecht THE NETHERLANDS
Country: Netherlands
Phone: 31-30-2121963
Fax: 31-30-2516554
Line Designation: hu


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 5 genomic features


STATEMENT OF RESEARCH INTERESTS
1. MicroRNA processing and function in zebrafish.
2. Development of genomic and genetic tools for zebrafish.


LAB MEMBERS
Ason, Brandon Post-Doc Kloosterman, Wigard Graduate Student Wienholds, Erno Graduate Student
de Bruijn, Ewart Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Kloosterman, W.P., Wienholds, E., Ketting, R.F., Plasterk, R.H. (2016) Expression of Concern: Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic acids research. 32(21):6284-6291
van Heesch, S., Simonis, M., van Roosmalen, M.J., Pillalamarri, V., Brand, H., Kuijk, E.W., de Luca, K.L., Lansu, N., Braat, A.K., Menelaou, A., Hao, W., Korving, J., Snijder, S., van der Veken, L.T., Hochstenbach, R., Knegt, A.C., Duran, K., Renkens, I., Alekozai, N., Jager, M., Vergult, S., Menten, B., de Bruijn, E., Boymans, S., Ippel, E., van Binsbergen, E., Talkowski, M.E., Lichtenbelt, K., Cuppen, E., Kloosterman, W.P. (2014) Genomic and functional overlap between somatic and germline chromosomal rearrangements. Cell Reports. 9:2001-10
Howe, K., Clark, M.D., Torroja, C.F., Torrance, J., Berthelot, C., Muffato, M., Collins, J.E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J.C., Koch, R., Rauch, G.J., White, S., Chow, W., Kilian, B., Quintais, L.T., Guerra-Assunção, J.A., Zhou, Y., Gu, Y., Yen, J., Vogel, J.H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S.F., Laird, G.K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Eliott, D., Threadgold, G., Harden, G., Ware, D., Mortimer, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C.M., Ersan-Ürün, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberländer, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., Rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N.P., Harrow, J., Ning, Z., Herrero, J., Searle, S.M., Enright, A., Geisler, R., Plasterk, R.H., Lee, C., Westerfield, M., de Jong, P.J., Zon, L.I., Postlethwait, J.H., Nüsslein-Volhard, C., Hubbard, T.J., Crollius, H.R., Rogers, J., and Stemple, D.L. (2013) The zebrafish reference genome sequence and its relationship to the human genome. Nature. 496:498-503
Kettleborough, R.N., Busch-Nentwich, E.M., Harvey, S.A., Dooley, C.M., de Bruijn, E., van Eeden, F., Sealy, I., White, R.J., Herd, C., Nijman, I.J., Fényes, F., Mehroke, S., Scahill, C., Gibbons, R., Wali, N., Carruthers, S., Hall, A., Yen, J., Cuppen, E., and Stemple, D.L. (2013) A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature. 496(7446):494-7
Kloos, W., Katus, H.A., and Meder, B. (2012) Genetic cardiomyopathies : Lessons learned from humans, mice, and zebrafish. Herz. 37(6):612-618
Gjini, E., Hekking, L.H., Küchler, A., Saharinen, P., Wienholds, E., Post, J.A., Alitalo, K., and Schulte-Merker, S. (2011) Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity. Disease models & mechanisms. 4(1):57-66
Li, H., Kloosterman, W., and Fekete, D.M. (2010) MicroRNA-183 Family Members Regulate Sensorineural Fates in the Inner Ear. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(9):3254-3263
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource and Hubrecht laboratory. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., Winkler, S., Brand, M., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource, MPI Dresden, and Hubrecht laboratory. ZFIN Direct Data Submission.
Pase, L., Layton, J.E., Kloosterman, W.P., Carradice, D., Waterhouse, P.M., and Lieschke, G.J. (2009) miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood. 113(8):1794-1804
de Bruijn, E., Cuppen, E., and Feitsma, H. (2009) Highly Efficient ENU Mutagenesis in Zebrafish. Meth. Mol. Biol.. 546:3-12
Feitsma, H., de Bruijn, E., van de Belt, J., Nijman, I.J., and Cuppen, E. (2008) Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line. Mutagenesis. 23(4):325-329
Muncan, V., Faro, A., Haramis, A.P., Hurlstone, A.F., Wienholds, E., van Es, J., Korving, J., Begthel, H., Zivkovic, D., and Clevers, H. (2007) T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine. EMBO reports. 8(10):966-973
Kloosterman, W.P., Lagendijk, A.K., Ketting, R.F., Moulton, J.D., and Plasterk, R.H. (2007) Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development. PLoS Biology. 5(8):e203
Houwing, S., Kamminga, L.M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D.V., Blaser, H., Raz, E., Moens, C.B., Plasterk, R.H., Hannon, G.J., Draper, B.W., and Ketting, R.F. (2007) A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell. 129(1):69-82
Kapsimali, M., Kloosterman, W.P., de Bruijn, E., Rosa, F., Plasterk, R.H., and Wilson, S.W. (2007) MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome biology. 8(8):R173
Ason, B., Darnell, D.K., Wittbrodt, B., Berezikov, E., Kloosterman, W.P., Wittbrodt, J., Antin, P.B., and Plasterk, R.H. (2006) Differences in vertebrate microRNA expression. Proc. Natl. Acad. Sci. USA. 103(39):14385-14389
Kloosterman, W.P., Steiner, F.A., Berezikov, E., de Bruijn, E., van de Belt, J., Verheul, M., Cuppen, E., and Plasterk, R.H. (2006) Cloning and expression of new microRNAs from zebrafish. Nucleic acids research. 34(9):2558-2569
Guryev, V., Koudijs, M.J., Berezikov, E., Johnson, S.L., Plasterk, R.H., van Eeden, F.J., and Cuppen, E. (2006) Genetic variation in the zebrafish. Genome research. 16(4):491-497
Kloosterman, W.P., Wienholds, E., de Bruijn, E., Kauppinen, S., and Plasterk, R.H. (2006) In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nature Methods. 3(1):27-29
Berezikov, E., and Plasterk, R.H. (2005) Camels and zebrafish, viruses and cancer: a microRNA update. Human Molecular Genetics. 14:183-190
Koudijs, M.J., den Broeder, M.J., Keijser, A., Wienholds, E., Houwing, S., van Rooijen, E.M., Geisler, R., and van Eeden, F.J. (2005) The Zebrafish Mutants dre, uki, and lep Encode Negative Regulators of the Hedgehog Signaling Pathway. PLoS Genetics. 1(2):e19
Wienholds, E., Kloosterman, W.P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, R.H., Kauppinen, S., and Plasterk, R.H. (2005) MicroRNA Expression in Zebrafish Embryonic Development. Science (New York, N.Y.). 309(5732):310-311
Berghmans,, S., Murphey, R.D., Wienholds, E., Neuberg, D., Kutok, J.L., Fletcher, C.D., Morris, J.P., Liu, T.X., Schulte-Merker, S., Kanki, J.P., Plasterk, R., Zon, L.I., and Look, A.T. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc. Natl. Acad. Sci. USA. 102(2):407-412
Kloosterman, W.P., Wienholds, E., Ketting, R.F., and Plasterk, R.H. (2004) Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic acids research. 32(21):6284-6291
Koch, R., Rauch, G.J., Humphray, S., Geisler, T.R., and Plasterk, R. (2004) Bacterial artificial chromosome (BAC) clones and the current clone map of the zebrafish genome. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:295-304
Wienholds, E., and Plasterk, R.H. (2004) Target-selected gene inactivation in zebrafish. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:69-90
Wienholds, E., van Eeden, F., Kosters, M., Mudde, J., Plasterk, R.H., and Cuppen, E. (2003) Efficient target-selected mutagenesis in zebrafish. Genome research. 13:2700-2707
Wienholds, E., Koudijs, M.J., van Eeden, F.J., Cuppen, E., and Plasterk, R.H. (2003) The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nature Genetics. 35(3):217-218
Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., and Clevers, H. (2003) The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature. 425(6958):633-637
Wienholds, E., Schulte-Merker, S., Walderich, B., and Plasterk, R.H.A. (2002) Target-selected inactivation of the zebrafish rag1 gene. Science (New York, N.Y.). 297(5578):99-102
Raz, E., Van Luenen, H.G.A.M., Schaerringer, B., Plasterk, R.H.A., and Driever, W. (1998) Transposition of the nematode Caenorhabditis elegans Tc3 element in the zebrafish Danio rerio. Current biology : CB. 8:82-88