OBO ID: GO:1990666
Term Name: PCSK9-LDLR complex Search Ontology:
Synonyms:
  • PCSK9.LDLR complex
  • PCSK9/LDL-R complex
  • PCSK9:EGF-A complex
  • PCSK9:low-density lipoprotein receptor complex
Definition: A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. (2)
References:
Ontology: GO: Cellular Component    QuickGO    AmiGO
EXPRESSION No data available
PHENOTYPE No data available