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General Information
ZIRC
OBO ID: GO:1990302
Term Name: Bre1-Rad6 ubiquitin ligase complex Search Ontology:
Synonyms:
  • Bre1-Rad6 complex
Definition: A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis.19531475
References:
  • IntAct:EBI-9102228
Ontology: GO: Cellular Component   QuickGO   AmiGO
EXPRESSION No data available
PHENOTYPE No data available