| Term Name: |
double-strand break repair via alternative nonhomologous end joining |
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Search Ontology:
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| Synonyms: |
- A-NHEJ
- alt-NHEJ
- double-strand break repair via microhomology-mediated end joining
- MMEJ
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| Definition: |
An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.
(3)
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| References: |
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| Ontology: |
GO: Biological Process
QuickGO
AmiGO
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