| OBO ID: GO:0071144 |
| Term Name: | heteromeric SMAD protein complex | Search Ontology: | |
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| Definition: | A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. (5) | ||
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| Ontology: | GO: Cellular Component QuickGO AmiGO |
Show first 5 Terms
EXPRESSION
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PHENOTYPE
No data available