OBO ID: GO:0070816
Term Name: phosphorylation of RNA polymerase II C-terminal domain Search Ontology:
Synonyms:
  • CTD domain phosphorylation of RNA polymerase II
  • generation of hyperphosphorylated CTD of RNA polymerase II
  • generation of II(0) form of RNA polymerase II
  • hyperphosphorylation of RNA polymerase II C-terminal domain
Definition: The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. 17079683
References:
Ontology: GO: Biological Process   QuickGO   AmiGO
PHENOTYPE No data available