OBO ID: GO:0061630
Term Name: ubiquitin protein ligase activity Search Ontology:
Synonyms:
  • APC-Cdc20 complex activity
  • APC-fizzy related complex activity
  • E3 involved in endoplasmic reticulum-associated degradation
  • ER-associated E3 ligase
  • protein ubiquitination activity
  • ubiquitin ligase activity involved in ER-associated degradation pathway
  • ubiquitin protein ligase activity involved in chloroplast disassembly
  • ubiquitin protein ligase activity involved in ER-associated degradation pathway
  • ubiquitin protein ligase activity involved in ERAD pathway
  • ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition
Definition: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.22863777
References:
  • Reactome:R-HSA-1225956
  • Reactome:R-HSA-1504190
  • Reactome:R-HSA-201445
  • Reactome:R-HSA-3322429
  • Reactome:R-HSA-3640861
  • Reactome:R-HSA-4608852
  • Reactome:R-HSA-4641129
  • Reactome:R-HSA-4641159
  • Reactome:R-HSA-4641246
  • Reactome:R-HSA-4641253
  • Reactome:R-HSA-5246693
  • Reactome:R-HSA-5610737
  • Reactome:R-HSA-5632648
  • Reactome:R-HSA-5635856
  • Reactome:R-HSA-5635864
  • Reactome:R-HSA-5654672
  • Reactome:R-HSA-5654677
  • Reactome:R-HSA-5654679
  • Reactome:R-HSA-5654684
  • Reactome:R-HSA-5658424
  • Reactome:R-HSA-5674022
  • Reactome:R-HSA-5682858
  • Reactome:R-HSA-5684071
  • Reactome:R-HSA-5687081
  • Reactome:R-HSA-5689111
  • Reactome:R-HSA-5690827
  • Reactome:R-HSA-6781867
  • Reactome:R-HSA-6782943
  • Reactome:R-HSA-6785361
  • Reactome:R-HSA-6790487
  • Reactome:R-HSA-6798373
  • Reactome:R-HSA-6804253
  • Reactome:R-HSA-6804441
  • Reactome:R-HSA-6804724
  • Reactome:R-HSA-6804879
  • Reactome:R-HSA-6804942
  • Reactome:R-HSA-6807106
  • Reactome:R-HSA-6807134
  • Reactome:R-HSA-68946
  • Reactome:R-HSA-69015
  • Reactome:R-HSA-8848829
  • Reactome:R-HSA-8851011
  • Reactome:R-HSA-8854041
  • Reactome:R-HSA-8854051
  • Reactome:R-HSA-8854628
  • Reactome:R-HSA-8866546
  • Reactome:R-HSA-8866856
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  • Reactome:R-HSA-8877003
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  • Reactome:R-HSA-8939335
  • Reactome:R-HSA-8939706
  • Reactome:R-HSA-8942101
  • Reactome:R-HSA-8943003
  • Reactome:R-HSA-8943040
  • Reactome:R-HSA-8943080
  • Reactome:R-HSA-8948775
  • Reactome:R-HSA-8948832
  • Reactome:R-HSA-8952382
  • Reactome:R-HSA-8952419
  • Reactome:R-HSA-8953946
  • Reactome:R-HSA-8956026
  • Reactome:R-HSA-8956684
  • Reactome:R-HSA-9008076
  • Reactome:R-HSA-9008479
  • Reactome:R-HSA-9009308
  • Reactome:R-HSA-9009403
  • Reactome:R-HSA-9011300
  • Reactome:R-HSA-9021523
  • Reactome:R-HSA-9033485
  • Reactome:R-HSA-934604
  • Reactome:R-HSA-936462
  • Reactome:R-HSA-936475
  • Reactome:R-HSA-9604629
  • Reactome:R-HSA-990526
Ontology: GO: Molecular Function   QuickGO   AmiGO
Relationships
is a type of:
has subtype:
negatively regulated by:
positively regulated by:
regulated by:
PHENOTYPE No data available