header logo image header logo text
Downloads Login
Research
General Information
ZIRC
OBO ID: GO:0036503
Term Name: ERAD pathway Search Ontology:
Synonyms:
  • endoplasmic reticulum-associated degradation
  • endoplasmic reticulum-associated protein degradation pathway
  • ER-associated degradation pathway
  • protein degradation by ERAD
Definition: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. (2)
References:
Ontology: GO: Biological Process   QuickGO   AmiGO
PHENOTYPE No data available