OBO ID: GO:0035333
Term Name: Notch receptor processing, ligand-dependent Search Ontology:
Synonyms:
  • Notch S2 cleavage
  • Notch S3 cleavage
Definition: The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). 12651094
References:
Ontology: GO: Biological Process   QuickGO   AmiGO
PHENOTYPE No data available