| OBO ID: GO:0008385 |
| Term Name: | IkappaB kinase complex | Search Ontology: | |
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| Definition: | A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (2) | ||
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| Ontology: | GO: Cellular Component QuickGO AmiGO |
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EXPRESSION
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PHENOTYPE
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