ZFIN GO: Biological Process: I-kappaB phosphorylation

OBO ID: GO:0007252

Term Name:	I-kappaB phosphorylation		Search Ontology:
Synonyms:	IkappaB phosphorylation IKB phosphorylation inhibitor of kappaB phosphorylation inhibitor of NF-kappaB phosphorylation
Definition:	The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (2)
References:
Ontology:	GO: Biological Process QuickGO AmiGO

Relationships

is part of:	canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction Show first 5 Terms
has parts:	IkappaB kinase activity IkappaB kinase activity Show first 5 Terms
is a type of:	protein phosphorylation protein phosphorylation Show first 5 Terms
negatively regulated by:	negative regulation of I-kappaB phosphorylation negative regulation of I-kappaB phosphorylation Show first 5 Terms
positively regulated by:	positive regulation of I-kappaB phosphorylation positive regulation of I-kappaB phosphorylation Show first 5 Terms
regulated by:	regulation of I-kappaB phosphorylation regulation of I-kappaB phosphorylation Show first 5 Terms

PHENOTYPE No data available