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ZIRC
OBO ID: GO:0007186
Term Name: G protein-coupled receptor signaling pathway Search Ontology:
Synonyms:
  • dimeric G-protein coupled receptor signaling pathway
  • dimeric G-protein coupled receptor signalling pathway
  • G protein coupled receptor protein signaling pathway
  • G protein coupled receptor protein signalling pathway
  • G-protein coupled receptor protein signal transduction
  • G-protein coupled receptor protein signaling pathway
  • G-protein coupled receptor signaling pathway via GPCR dimer
  • G-protein coupled receptor signalling pathway
  • G-protein-coupled receptor protein signalling pathway
  • GPCR signaling pathway
  • GPCR signalling pathway
Definition: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. (3)
References:
  • MIPS_funcat:30.01.05.05
  • MIPS_funcat:30.05.02.24
Ontology: GO: Biological Process   QuickGO   AmiGO
Relationships
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PHENOTYPE No data available