OBO ID: GO:0006273
Term Name: lagging strand elongation Search Ontology:
Synonyms:
Definition: The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. (2)
References:
Ontology: GO: Biological Process   QuickGO   AmiGO
PHENOTYPE No data available