Term Name: |
Rab geranylgeranyltransferase activity |
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Search Ontology:
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Synonyms: |
- geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
- GGTase-II activity
- GGTaseII activity
- protein geranylgeranyltransferase type II activity
- Rab-protein geranylgeranyltransferase activity
- RabGGTase activity
- type II protein geranyl-geranyltransferase activity
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Definition: |
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
(2)
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References: |
- EC:2.5.1.60
- MetaCyc:RXN-19995
- MetaCyc:RXN-19996
- MetaCyc:RXN-19997
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Ontology: |
GO: Molecular Function
QuickGO
AmiGO
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