OBO ID: GO:0003810 |
Term Name: | protein-glutamine gamma-glutamyltransferase activity | Search Ontology: | |
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Definition: | Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. 2.3.2.13 | ||
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Ontology: | GO: Molecular Function QuickGO AmiGO |
Relationships
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PHENOTYPE
No data available