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OBO ID: GO:0003712
Term Name: transcription coregulator activity Search Ontology:
  • RNA polymerase II transcriptional cofactor activity
  • transcription cofactor activity
  • transcriptional co-regulator
Definition: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators. (5)
Ontology: GO: Molecular Function   QuickGO   AmiGO
PHENOTYPE No data available