header logo image header logo text
Downloads Login
Research
General Information
ZIRC
OBO ID: GO:0000703
Term Name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity Search Ontology:
Synonyms:
  • bifunctional DNA glycosylase
  • DNA glycosylase/AP-lyase
  • DNA glycosylase/beta-lyase
  • endodeoxyribonuclease III
  • endonuclease III
  • endonuclease VIII activity
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
  • pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
Definition: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.11554296
References:
  • Reactome:R-HSA-110224
  • Reactome:R-HSA-110226
  • Reactome:R-HSA-110227
Ontology: GO: Molecular Function   QuickGO   AmiGO
PHENOTYPE No data available