ZFIN GO: Biological Process: MAPK cascade

OBO ID: GO:0000165

Term Name:	MAPK cascade		Search Ontology:
Synonyms:	ERK/MAPK cascade MAP kinase cascade MAP kinase kinase kinase cascade MAPK signal transduction MAPK signaling MAPK signalling MAPKKK cascade MAPKKK cascade during sporulation mitogen-activated protein kinase cascade
Definition:	An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. (2)
References:	Wikipedia:MAPK_cascade Wikipedia:Mitogen-activated_protein_kinase
Ontology:	GO: Biological Process QuickGO AmiGO

Relationships

has parts:	MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP-kinase scaffold activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP-kinase scaffold activity Show first 5 Terms
is a type of:	intracellular signaling cassette intracellular signaling cassette Show first 5 Terms
has subtype:	ERK1 and ERK2 cascade ERK5 cascade JNK cascade p38MAPK cascade pheromone response MAPK cascade ... Show All 6 Terms ERK1 and ERK2 cascade ERK5 cascade JNK cascade p38MAPK cascade pheromone response MAPK cascade stress-activated MAPK cascade Show first 5 Terms
negatively regulated by:	negative regulation of MAPK cascade negative regulation of MAPK cascade Show first 5 Terms
positively regulated by:	positive regulation of MAPK cascade positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway positive regulation of MAPK cascade positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Show first 5 Terms
regulated by:	regulation of MAPK cascade regulation of MAPK cascade Show first 5 Terms

PHENOTYPE