ZFIN Human Disease: bronchiectasis

OBO ID: DOID:9563

Term Name:	bronchiectasis		Search Ontology:
Synonyms:	Polynesian bronchiectasis
Definition:	A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (2)
References:	ICD10CM:J47 ICD9CM:494 MESH:D001987 NCI:C84475 OMIM:211400 OMIM:613021 OMIM:613071 OMIM:PS211400 ORDO:60033 SNOMEDCT_US_2023_03_01:155580000 UMLS_CUI:C0006267
Ontology:	Human Disease ( DOID:9563 )

Relationships

is a type of:	bronchial disease bronchial disease Show first 5 Terms
has subtype:	bronchiectasis 1 bronchiectasis 2 bronchiectasis 3 bronchiectasis 1 bronchiectasis 2 bronchiectasis 3 Show first 5 Terms

OTHER bronchiectasis PAGES

Alliance (1)

GENES INVOLVED

Human Gene	Zebrafish Ortholog	OMIM Term	OMIM Phenotype ID
CFTR	cftr	{Bronchiectasis with or without elevated sweat chloride 1, modifier of}	211400
SCNN1A		Bronchiectasis with or without elevated sweat chloride 2
SCNN1B		Bronchiectasis with or without elevated sweat chloride 1
SCNN1G		Bronchiectasis with or without elevated sweat chloride 3

ZEBRAFISH MODELS No data available

PHENOTYPE No data available

CITATIONS: None