OBO ID: DOID:3883 |
Term Name: | Lynch syndrome | Search Ontology: | |
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Definition: | An autosomal dominant disease that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers. (2) | ||
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Ontology: | Human Disease (DOID:3883) |
Human Gene | Zebrafish Ortholog | OMIM Term | OMIM Phenotype ID |
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EPCAM | Colorectal cancer, hereditary nonpolyposis, type 8 | 613244 | |
MLH1 | Colorectal cancer, hereditary nonpolyposis, type 2 | 609310 | |
MLH3 | Colorectal cancer, hereditary nonpolyposis, type 7 | 614385 | |
MSH2 | Colorectal cancer, hereditary nonpolyposis, type 1 | 120435 | |
MSH6 | Colorectal cancer, hereditary nonpolyposis, type 5 | 614350 | |
PMS2 | Colorectal cancer, hereditary nonpolyposis, type 4 | 614337 | |
TGFBR2 | Colorectal cancer, hereditary nonpolyposis, type 6 | 614331 |