OBO ID: DOID:3883
Term Name: Lynch syndrome Search Ontology:
Synonyms:
  • COCA 1
  • Hereditary Defective Mismatch Repair syndrome
  • hereditary non-polyposis colon cancer type 1
  • hereditary nonpolyposis colorectal cancer
  • hereditary nonpolyposis colorectal neoplasm
  • HNPCC - hereditary nonpolyposis colon cancer
Definition: An autosomal dominant disease that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers. (2)
References:
Ontology: Human Disease   (DOID:3883)
Relationships
is a type of:
has subtype:
OTHER Lynch syndrome PAGES
GENES INVOLVED
Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID
EPCAM Colorectal cancer, hereditary nonpolyposis, type 8 613244
MLH1 Colorectal cancer, hereditary nonpolyposis, type 2 609310
MLH3 Colorectal cancer, hereditary nonpolyposis, type 7 614385
MSH2 Colorectal cancer, hereditary nonpolyposis, type 1 120435
MSH6 Colorectal cancer, hereditary nonpolyposis, type 5 614350
PMS2 Colorectal cancer, hereditary nonpolyposis, type 4 614337
TGFBR2 Colorectal cancer, hereditary nonpolyposis, type 6 614331
ZEBRAFISH MODELSNo data available
PHENOTYPE No data available

CITATIONS: None