OBO ID: DOID:10652
Term Name: Alzheimer's disease Search Ontology:
Synonyms:
  • Alzheimer disease
  • Alzheimers dementia
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (3)
References:
  • EFO:0000249
  • GARD:10254
  • ICD10CM:G30
  • ICD9CM:331.0
  • KEGG:05010
  • MESH:D000544
  • NCI:C2866
  • SNOMEDCT_US_2022_09_01:73768007
  • UMLS_CUI:C0002395
Ontology: Human Disease   (DOID:10652)
Relationships
is a type of:
has subtype:
OTHER Alzheimer's disease PAGES
GENES INVOLVED No data available
ZEBRAFISH MODELS
Fish Conditions Citations
AB chemical treatment by environment: aluminium trichloride Li et al., 2021
chemical treatment by environment: aluminium trichloride Sun et al., 2022
chemical treatment by injection: amyloid-beta Javed et al., 2020
chemical treatment by environment: okadaic acid Koehler et al., 2018
chemical treatment by environment: okadaic acid Koehler et al., 2018
WT chemical treatment by injection: amyloid-beta polypeptide 42 Bhattarai et al., 2017
chemical treatment by injection: amyloid-beta polypeptide 42 Cosacak et al., 2017
chemical treatment by injection: amyloid-beta polypeptide 42 Bhattarai et al., 2016
chemical treatment by injection: amyloid-beta polypeptide 42 Bhattarai et al., 2017
chemical treatment by injection: amyloid-beta polypeptide 42 Kizil et al., 2022
chemical treatment by injection: amyloid-beta polypeptide 42 Turgutalp et al., 2022
chemical treatment by environment: aluminium trichloride Sang et al., 2020
chemical treatment by environment: aluminium trichloride Miao et al., 2022
chemical treatment by environment: aluminium trichloride Sang et al., 2018
chemical treatment by environment: aluminium trichloride Wang et al., 2021
chemical treatment by environment: aluminium trichloride Sang et al., 2020
chemical treatment by injection: amyloid-beta polypeptide 42 Reinhardt et al., 2019
chemical treatment: okadaic acid Nada et al., 2016
chemical treatment by environment: scopolamine Singsai et al., 2021
psen1uaa9/+ standard conditions Dong et al., 2021
psen1uaa10/+ standard conditions Hin et al., 2020
y83Tg chemical treatment by injection: amyloid-beta polypeptide 42 Cosacak et al., 2019
c426Tg; ync1Tg lighting conditions Lim et al., 2020
PHENOTYPE No data available

CITATIONS (49)
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