OBO ID: CHEBI:92369
Term Name: SU4312 Search Ontology:
Synonyms:
  • 3-(4-dimethylamino-benzylidenyl)-2-indolinone
  • 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one
  • 3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
  • DMBI
  • SU 4312
  • SU-4312
Definition: A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
References:
Ontology: Chebi
PHENOTYPE No data available